The Garvan Institute of Medical Research, Sydney, New South Wales, Australia; The Kinghorn Cancer Center, Sydney, New South Wales, Australia; St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.
Cancer Research UK, The Beatson Institute for Cancer Research, Glasgow, Scotland, United Kingdom.
Gastroenterology. 2018 Mar;154(4):820-838. doi: 10.1053/j.gastro.2017.11.280. Epub 2017 Dec 26.
Pancreatic cancer is accompanied by a fibrotic reaction that alters interactions between tumor cells and the stroma to promote tumor progression. Consequently, strategies to target the tumor stroma might be used to treat patients with pancreatic cancer. We review recently developed approaches for reshaping the pancreatic tumor stroma and discuss how these might improve patient outcomes. We also describe relationships between the pancreatic tumor extracellular matrix, the vasculature, the immune system, and metabolism, and discuss the implications for the development of stromal compartment-specific therapies.
胰腺癌伴随着纤维化反应，这种反应改变了肿瘤细胞与基质之间的相互作用，促进了肿瘤的进展。因此，靶向肿瘤基质的策略可能被用于治疗胰腺癌患者。我们综述了最近用于重塑胰腺肿瘤基质的方法，并讨论了这些方法如何改善患者的预后。我们还描述了胰腺肿瘤细胞外基质、血管、免疫系统和代谢之间的关系，并讨论了这些关系对基质特定部位治疗方法发展的影响。
