伊曲康唑在小鼠芽生菌病模型中的疗效及与酮康唑的比较。

Efficacy of itraconazole in blastomycosis in a murine model and comparison with ketoconazole.

作者信息

Arathoon E G, Brummer E, Stevens D A

出版信息

Mycoses. 1989;32 Suppl 1:109-12. doi: 10.1111/j.1439-0507.1989.tb02300.x.

DOI:10.1111/j.1439-0507.1989.tb02300.x

Abstract

Mice were infected intranasally with B. dermatitidis yeasts, and after infection treated orally. Itraconazole 50-150 mg/kg/day was protective (prolonged survival) against lethal infection, although the infection was not sterilized. Itraconazole was approximately 3 times as potent as ketoconazole. These results suggest advantages for itraconazole therapy clinically.

摘要

将皮炎芽生菌酵母经鼻内感染小鼠，感染后进行口服治疗。伊曲康唑50 - 150毫克/千克/天对致死性感染具有保护作用（延长生存期），尽管感染未被清除。伊曲康唑的效力约为酮康唑的3倍。这些结果提示伊曲康唑在临床治疗上具有优势。