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新型口服三唑类药物ICI 195,739与酮康唑治疗实验性小鼠芽生菌病的活性比较。

Activity of ICI 195,739, a new oral triazole, compared with that of ketoconazole in the therapy of experimental murine blastomycosis.

作者信息

Tucker R M, Hanson L H, Brummer E, Stevens D A

机构信息

Department of Medicine, Santa Clara Valley Medical Center and Institute for Medical Research, San Jose, California 95128.

出版信息

Antimicrob Agents Chemother. 1989 Apr;33(4):573-5. doi: 10.1128/AAC.33.4.573.

DOI:10.1128/AAC.33.4.573
PMID:2729949
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC172482/
Abstract

ICI 195,739, a novel orally active triazole, proved 50 times as potent as ketoconazole, produced a clinical cure, and completely eradicated residual infection in a murine model of pulmonary blastomycosis. No other previously tested azole has shown similar activity. Fungicidal activity against Blastomyces dermatitidis was seen in vitro at concentrations 1/40 of those achieved in serum with protective doses.

摘要

ICI 195,739是一种新型口服活性三唑类药物，其效力被证明是酮康唑的50倍，在小鼠肺芽生菌病模型中产生了临床治愈效果，并完全根除了残留感染。此前测试的其他唑类药物均未显示出类似活性。在体外，对皮炎芽生菌的杀菌活性在浓度为血清中达到保护剂量时浓度的1/40时即可观察到。

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1
Activity of ICI 195,739, a new oral triazole, compared with that of ketoconazole in the therapy of experimental murine blastomycosis.新型口服三唑类药物ICI 195,739与酮康唑治疗实验性小鼠芽生菌病的活性比较。
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引用本文的文献

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本文引用的文献

1
Experience with ketoconazole in three major manifestations of progressive coccidioidomycosis.酮康唑治疗进行性球孢子菌病三种主要表现形式的经验。
Am J Med. 1983 Jan 24;74(1B):58-63. doi: 10.1016/0002-9343(83)90515-6.
2
Treatment of systemic mycoses with ketoconazole: emphasis on toxicity and clinical response in 52 patients. National Institute of Allergy and Infectious Diseases collaborative antifungal study.酮康唑治疗系统性真菌病：52例患者的毒性及临床反应重点。美国国立过敏和传染病研究所抗真菌协作研究。
Ann Intern Med. 1983 Jan;98(1):13-20. doi: 10.7326/0003-4819-98-1-13.
3
Activities of the modified polyene N-D-ornithyl amphotericin methyl ester and the azoles ICI 153066, Bay n 7133, and Bay l 9139 compared with those of amphotericin B and ketoconazole in the therapy of experimental blastomycosis.将修饰的多烯类药物N-D-鸟氨酰两性霉素甲酯与唑类药物ICI 153066、Bay n 7133和Bay l 9139的活性与两性霉素B和酮康唑在实验性芽生菌病治疗中的活性进行比较。
Antimicrob Agents Chemother. 1985 Mar;27(3):363-6. doi: 10.1128/AAC.27.3.363.
4
Activity of ICI 195,739--a novel, orally active bistriazole--in rodent models of fungal and protozoal infections.ICI 195,739（一种新型口服活性双三唑）在真菌和原生动物感染啮齿动物模型中的活性。
Ann N Y Acad Sci. 1988;544:310-28. doi: 10.1111/j.1749-6632.1988.tb40416.x.
5
Treatment of mycoses with itraconazole.伊曲康唑治疗真菌病。
Ann N Y Acad Sci. 1988;544:451-70. doi: 10.1111/j.1749-6632.1988.tb40443.x.
6
Antimicrobial susceptibility testing of yeasts: a turbidimetric technique independent of inoculum size.酵母的药敏试验：一种与接种量无关的比浊法技术。
Antimicrob Agents Chemother. 1976 Oct;10(4):721-8. doi: 10.1128/AAC.10.4.721.
7
Mouse model of pulmonary blastomycosis: utility, simplicity, and quantitative parameters.
Am Rev Respir Dis. 1978 Apr;117(4):695-703. doi: 10.1164/arrd.1978.117.4.695.