新型口服三唑类药物ICI 195,739与酮康唑治疗实验性小鼠芽生菌病的活性比较。
Activity of ICI 195,739, a new oral triazole, compared with that of ketoconazole in the therapy of experimental murine blastomycosis.
作者信息
Tucker R M, Hanson L H, Brummer E, Stevens D A
机构信息
Department of Medicine, Santa Clara Valley Medical Center and Institute for Medical Research, San Jose, California 95128.
出版信息
Antimicrob Agents Chemother. 1989 Apr;33(4):573-5. doi: 10.1128/AAC.33.4.573.
Abstract
ICI 195,739, a novel orally active triazole, proved 50 times as potent as ketoconazole, produced a clinical cure, and completely eradicated residual infection in a murine model of pulmonary blastomycosis. No other previously tested azole has shown similar activity. Fungicidal activity against Blastomyces dermatitidis was seen in vitro at concentrations 1/40 of those achieved in serum with protective doses.
摘要
ICI 195,739是一种新型口服活性三唑类药物，其效力被证明是酮康唑的50倍，在小鼠肺芽生菌病模型中产生了临床治愈效果，并完全根除了残留感染。此前测试的其他唑类药物均未显示出类似活性。在体外，对皮炎芽生菌的杀菌活性在浓度为血清中达到保护剂量时浓度的1/40时即可观察到。
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