Zdrojewicz Zygmunt, Molendowska Agnieszka
Pediatr Endocrinol Diabetes Metab. 2013;20(1):17-22.
Circadian rhythm plays an important role in human physiology. Its abnormal functioning results, among others, in jet lag disorder (JLD- Jet Lag Disorder), which is a discomfort experienced by people travelling between time zones, as well as being the cause for metabolic diseases in people working shifts. Recent studies have shown the role of vasopressin V1a and V1b suprachiasmatic nucleus (SCN- surachiasmatic nucleus) of the hypothalamus in the regulation of circadian rhythms. Mice genetically lacking receptors are resistant to disturbances of circadian rhythm, and are characterized by an almost immediate adjustment to the new rhythm. A similar effect is achieved by pharmacologically blocking V1a and V1b receptors. Research gives hope of overcoming this disorder to travellers who traverse time zones at high speed, as well as creating the possibility of adaptation to shift work without provoking any negative consequences over one´s health.
昼夜节律在人体生理中起着重要作用。其功能异常会导致多种后果，其中包括时差紊乱（JLD），这是跨时区旅行者所经历的不适，也是轮班工作人群患代谢性疾病的原因。最近的研究表明，下丘脑视交叉上核（SCN）中的血管加压素V1a和V1b在昼夜节律调节中发挥作用。基因缺乏受体的小鼠对昼夜节律紊乱具有抗性，其特点是几乎能立即适应新节律。通过药理学方法阻断V1a和V1b受体也能达到类似效果。该研究为高速穿越时区的旅行者克服这种紊乱带来了希望，同时也为适应轮班工作而不引发任何对健康的负面影响创造了可能性。
