Maeda T, Ashie T, Kikuiri K, Ishiyama N, Takakura M, Ise T
Department of Medicine, Nippon Steel Corporation Muroran Works Hospital, Muroran, Japan.
Jpn J Med. 1989 Nov-Dec;28(6):709-16. doi: 10.2169/internalmedicine1962.28.709.
A 65-year-old woman had chronic myelomonocytic leukemia with peripheral neuropathy and IgA paraprotein with kappa type light chain. Plasma cells with "flaming" cytoplasma were seen in the bone marrow specimens. The findings suggest that chronic myelomonocytic leukemia may involve B-lymphocytes in the proliferative process and that it may be a clonal disease. Moreover, this case was associated with peripheral sensori-motor polyneuropathy. The disorder was responsive to prednisolone, as oral administration of prednisolone improved not only the peripheral polyneuropathy, but also the hematological findings. Serum vitamin B12 and lysozyme in the serum and urine were decreased by the steroid therapy. The administration of prednisolone is effective not only for polyneuropathy but also chronic myelomonocytic leukemia.
一名65岁女性患有慢性粒单核细胞白血病，伴有周围神经病变和κ型轻链IgA副蛋白。在骨髓标本中可见具有“火焰状”细胞质的浆细胞。这些发现表明，慢性粒单核细胞白血病在增殖过程中可能涉及B淋巴细胞，并且可能是一种克隆性疾病。此外，该病例与周围感觉运动性多神经病相关。该疾病对泼尼松龙有反应，因为口服泼尼松龙不仅改善了周围性多神经病，还改善了血液学表现。类固醇治疗使血清维生素B12以及血清和尿液中的溶菌酶降低。泼尼松龙的给药不仅对多神经病有效，而且对慢性粒单核细胞白血病也有效。
