Lucia H L, Coppenhaver D H, Baron S
Department of Pathology, Microbiology and Pediatrics, University of Texas Medical Branch, Galveston 77550.
Antiviral Res. 1989 Dec;12(5-6):279-92. doi: 10.1016/0166-3542(89)90055-7.
Human arenaviral infections have a high mortality, and are dangerous to work with in the laboratory. There is a need for good antiviral agents to treat these infections. Pichinde virus infection of the inbred strain 13 guinea pig is a relatively safe, good animal model for human arenavirus infections. Mortality is consistently 100% between days 12 and 25 (mean 14.8) days after infection. When infected animals were treated with recombinant human interferon alpha A, or with CL246,783, an immunomodulator known to induce interferon, no beneficial effect was noted. When animals received ribavirin, 25 mg/kg/day for the first 14 days of infection, the course of infection was prolonged, with death occurring a mean of 22.5 days after infection. If ribavirin was administered for 28 days, mortality was reduced to 25%, with those animals dying a mean of 21.0 days after infection. These results confirm the studies that indicate that ribavirin is a useful agent for treating arenaviral infections. However, treatment with this agent must be prolonged. They also demonstrate the potential usefulness of Pichinde virus infection in strain 13 guinea pigs as an animal model of human disease.
人类沙粒病毒感染死亡率很高，在实验室中处理这类病毒很危险。因此需要优良的抗病毒药物来治疗这些感染。近交系13豚鼠感染皮钦德病毒是一种相对安全的、用于人类沙粒病毒感染的良好动物模型。感染后第12至25天（平均14.8天）死亡率始终为100%。用重组人αA干扰素或CL246,783（一种已知可诱导干扰素的免疫调节剂）治疗感染动物，未观察到有益效果。感染动物在感染的前14天接受25mg/kg/天的利巴韦林治疗时，感染病程延长，平均在感染后22.5天死亡。如果利巴韦林给药28天，死亡率降至25%，这些动物平均在感染后21.0天死亡。这些结果证实了表明利巴韦林是治疗沙粒病毒感染有用药物的研究。然而，使用该药物治疗必须延长疗程。它们还证明了13系豚鼠感染皮钦德病毒作为人类疾病动物模型的潜在用途。
