利巴韦林和三丁基利巴韦林对豚鼠阿根廷出血热（胡宁病毒）的影响。
Effect of ribavirin and tributylribavirin on argentine hemorrhagic fever (Junin virus) in guinea pigs.
作者信息
Kenyon R H, Canonico P G, Green D E, Peters C J
出版信息
Antimicrob Agents Chemother. 1986 Mar;29(3):521-3. doi: 10.1128/AAC.29.3.521.
Abstract
Subcutaneous injections of ribavirin into guinea pigs infected intraperitoneally or intracerebrally with Junin virus significantly increased the mean time to death but did not enhance survival of the animals. We found similar results with tributylribavirin. Virus replication was delayed, but not prevented, in ribavirin-treated infected guinea pigs. The animals usually died with high virus titers in their brains and frequently were paralyzed.
摘要
给经腹腔或脑内接种胡宁病毒的豚鼠皮下注射利巴韦林，可显著延长其平均死亡时间，但不能提高动物的存活率。我们使用三丁基利巴韦林也得到了类似的结果。在接受利巴韦林治疗的受感染豚鼠中，病毒复制被延迟，但并未被阻止。这些动物通常在脑内病毒滴度很高的情况下死亡，并且经常出现瘫痪症状。
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