Piskin B, Karakoc O, Genc H, Akay S, Sipahi C, Erdem M, Karaman B, Gorgulu S, Yetkin S, Ayyildiz S
Department of Prosthodontics, Gulhane Military Medical Academy, Ankara, Turkey.
J Orofac Orthop. 2015 Jan;76(1):51-65. doi: 10.1007/s00056-014-0259-z. Epub 2015 Jan 22.
Despite numerous studies investigating the dimensional and therapeutic effects of mandibular advancement splints (MASs), data regarding the effects of differently designed individual and non-adjustable MASs on the upper airway in fully dentate apneic subjects in the sagittal plane including comparison of these effects with a placebo device are sparse. The present study aimed to determine the dimensional changes in the sagittal plane created by differently designed MASs in the upper airway in fully dentate apneic subjects and to compare these changes with the effects of a placebo device.
Magnetic resonance (MR) images of 9 dentate apneic subjects with 5 differently designed MASs and without a MAS were obtained. We measured the area of the entire pharynx (velopharynx, oropharynx, hypopharynx) on these MR images and compared the dimensional changes.
The dimensional changes triggered by two specific MASs (75% of the maximum mandibular protrusion with 5 mm vertical opening, and 75% of the maximum mandibular protrusion with 10 mm of vertical opening) in the entire pharynx in the sagittal plane were statistically significant compared to the other MASs (p < 0.05). The MAS effecting 75% of the maximum mandibular protrusion and 10 mm of vertical opening created a significant dimensional increase only in the velopharyngeal area among the three pharyngeal sites (p ≤ 0.003).
While the degree of mandibular protrusion created by the MAS affects the dimensions of the upper airway, the degree of the vertical opening exerts no significant dimensional effect in the sagittal plane in fully dentate apneic patients. The mandibular protrusion effect is comparatively larger in the velopharyngeal region.
尽管有大量研究探讨下颌前移矫治器(MAS)的尺寸和治疗效果,但关于不同设计的个体化且不可调节的MAS对全口牙列睡眠呼吸暂停患者矢状面上气道影响的数据,包括将这些影响与安慰剂装置进行比较的数据却很稀少。本研究旨在确定不同设计的MAS在全口牙列睡眠呼吸暂停患者上气道矢状面所产生的尺寸变化,并将这些变化与安慰剂装置的效果进行比较。
获取了9名全口牙列睡眠呼吸暂停患者佩戴5种不同设计的MAS以及不佩戴MAS时的磁共振(MR)图像。我们在这些MR图像上测量了整个咽部(鼻咽、口咽、下咽)的面积,并比较了尺寸变化。
与其他MAS相比,两种特定的MAS(最大下颌前伸的75%且垂直开口5mm,以及最大下颌前伸的75%且垂直开口10mm)在矢状面整个咽部所引发的尺寸变化具有统计学意义(p<0.05)。在三个咽部区域中,产生最大下颌前伸75%且垂直开口10mm的MAS仅在鼻咽区域产生了显著的尺寸增加(p≤0.003)。
虽然MAS产生的下颌前伸程度会影响上气道尺寸,但垂直开口程度在全口牙列睡眠呼吸暂停患者的矢状面并未产生显著的尺寸影响。下颌前伸效应在鼻咽区域相对较大。