Sanna G, Farci P, Busonera B, Murgia G, La Colla P, Giliberti G
a Department of Biomedical Sciences , University of Cagliari, Cittadella Universitaria Monserrato , Cagliari , Italy.
b Department of Inorganic and Analytical Chemistry , University of Cagliari, Cittadella Universitaria Monserrato , Cagliari , Italy.
Nat Prod Res. 2015;29(22):2065-70. doi: 10.1080/14786419.2014.1003187. Epub 2015 Jan 23.
Natural products are a successful source in drug discovery, playing a significant role in maintaining human health. We investigated the in vitro cytotoxicity and antiviral activity of extracts from 18 traditionally used Mediterranean plants. Noteworthy antiviral activity was found in the extract obtained from the branches of Daphne gnidium L. against human immunodeficiency virus type-1 (EC50 = 0.08 μg/mL) and coxsackievirus B5 (EC50 = 0.10 μg/mL). Other relevant activities were found against BVDV, YFV, Sb-1, RSV and HSV-1. Interestingly, extracts from Artemisia arborescens L. and Rubus ulmifolius Schott, as well as those from D. gnidium L., showed activities against two different viruses. This extensive antiviral screening allowed us to identify attractive activities, offering opportunities to develop lead compounds with a great pharmaceutical potential.
天然产物是药物发现的成功来源，在维护人类健康方面发挥着重要作用。我们研究了18种传统使用的地中海植物提取物的体外细胞毒性和抗病毒活性。从瑞香狼毒的枝条中获得的提取物对1型人类免疫缺陷病毒（EC50 = 0.08 μg/mL）和柯萨奇病毒B5（EC50 = 0.10 μg/mL）具有显著的抗病毒活性。还发现了对牛病毒性腹泻病毒、黄热病病毒、Sb-1、呼吸道合胞病毒和单纯疱疹病毒1型的其他相关活性。有趣的是，青蒿和榆叶悬钩子的提取物以及瑞香狼毒的提取物对两种不同的病毒都有活性。这种广泛的抗病毒筛选使我们能够识别出有吸引力的活性，为开发具有巨大制药潜力的先导化合物提供了机会。
