Chen Faming, Li Junhua, Sun Biancheng, Zhang Hong, Zhang Rusheng, Yuan Jie, Ou Xinhua, Ye Wen, Chen Jingfang, Liu Yunzhi, Huang Yiwei
Changsha Center for Disease Control and Prevention, Changsha, Hunan, 410001, China.
Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan, China.
Int J Infect Dis. 2015 Apr;33:130-1. doi: 10.1016/j.ijid.2015.01.013. Epub 2015 Jan 19.
A novel H7N9 virus (A/Changsha/1/2013(H7N9)) identified through routine examination in the influenza network laboratory was analyzed retrospectively. The gene sequences of A/Changsha/1/2013(H7N9) were highly homologous to other viruses isolated in mainland China. Mutations of Q226L and G186V were found in the hemagglutinin protein (HA). Amino acid deletions were found at positions 69-73 of the neuraminidase protein (NA) and 218-230 of the non-structural protein (NS1). All viral genes except PB1 were essentially identical to the sequences of other Chinese influenza A H7N9 isolates. Overall, A/Changsha/1/2013(H7N9) is highly homologous to other H7N9 avian influenza viruses isolated in mainland China.
通过流感网络实验室的常规检测鉴定出的一种新型H7N9病毒（A/长沙/1/2013(H7N9)）进行了回顾性分析。A/长沙/1/2013(H7N9)的基因序列与中国大陆分离出的其他病毒高度同源。在血凝素蛋白（HA）中发现了Q226L和G186V突变。在神经氨酸酶蛋白（NA）的69 - 73位和非结构蛋白（NS1）的218 - 230位发现了氨基酸缺失。除PB1外，所有病毒基因与其他中国甲型H7N9流感病毒分离株的序列基本相同。总体而言，A/长沙/1/2013(H7N9)与中国大陆分离出的其他H7N9禽流感病毒高度同源。
