益生元对接受肠内营养的老年患者流感疫苗接种效果的增强作用

Enhanced vaccination effect against influenza by prebiotics in elderly patients receiving enteral nutrition.

作者信息

Akatsu Hiroyasu, Nagafuchi Shinya, Kurihara Rina, Okuda Kenji, Kanesaka Takeshi, Ogawa Norihiro, Kanematsu Takayoshi, Takasugi Satoshi, Yamaji Taketo, Takami Masao, Yamamoto Takayuki, Ohara Hirotaka, Maruyama Mitsuo

机构信息

Department of Medicine for Aging Place, Community Health Care/Community-Based Medical Education, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan.

Choju Medical Institute, Fukushimura Hospital, Toyohashi, Aichi, Japan.

出版信息

Geriatr Gerontol Int. 2016 Feb;16(2):205-13. doi: 10.1111/ggi.12454. Epub 2015 Jan 22.

DOI:10.1111/ggi.12454

PMID:25613751

Abstract

AIM

We investigated the effect of prebiotics on the immunological response after influenza vaccination in enterally fed elderly individuals. The intervention group was given an enteral formula containing lactic acid bacteria-fermented milk products. In addition, two different types of other prebiotics, galacto-oligosaccharide and bifidogenic growth stimulator, were also given. The two prebiotics improved intestinal microbiota differently. In a control group, a standard formula without prebiotics was given.

METHODS

An enteral formula with (intervention group [F]) or without (control group [C]) prebiotics was given through percutaneous endoscopic gastrostomy to elderly participants for 10 weeks. Influenza vaccine was inoculated at week 4. Nutritional and biochemical indices, intestinal micro bacteria and immunological indices were analyzed.

RESULTS

The Bifidobacterium count in groups F and C at week 0 was 6.4 ± 1.9 and 6.6 ± 3.0 (log10 [count/g feces]), respectively. Although the count in group C decreased at week 10, the count in group F increased. The Bacteroides count in group F increased from 10.7 ± 0.9 to 11.4 ± 0.5, but decreased in group C from 11.2 ± 0.2 to 10.7 ± 0.4. Although the enhanced titers of H1N1, H3N2 and B antigens against the vaccine decreased thereafter in group C, these enhanced titers in group F could be maintained.

CONCLUSION

Our findings suggest that prebiotics affect the intestinal microbiota and might maintain the antibody titers in elderly individuals.

摘要

目的

我们研究了益生元对经肠内喂养的老年人接种流感疫苗后免疫反应的影响。干预组给予含乳酸菌发酵奶制品的肠内配方奶粉。此外，还给予了两种不同类型的其他益生元，即低聚半乳糖和双歧杆菌生长刺激剂。这两种益生元对肠道微生物群的改善作用不同。对照组给予不含益生元的标准配方奶粉。

方法

通过经皮内镜下胃造口术，给老年参与者给予含（干预组[F]）或不含（对照组[C]）益生元的肠内配方奶粉，持续10周。在第4周接种流感疫苗。分析营养和生化指标、肠道微生物和免疫指标。

结果

第0周时，F组和C组的双歧杆菌计数分别为6.4±1.9和6.6±3.0（log10[计数/g粪便]）。虽然C组的计数在第10周下降，但F组的计数增加。F组的拟杆菌计数从10.7±0.9增加到11.4±0.5，而C组从11.2±0.2下降到10.7±0.4。虽然C组中针对疫苗的H1N1、H3N2和B抗原的增强滴度此后下降，但F组中的这些增强滴度得以维持。