Ducloux Didier, Legendre Mathieu, Bamoulid Jamal, Saas Philippe, Courivaud Cécile, Crepin Thomas
Inserm, UMR1098, Federation Hospitalo-Universitaire INCREASE, Besançon, France.
University Bourgogne Franche-Comté, Faculté de Médecine et de Pharmacie, LabEx LipSTIC, Besançon, France.
Front Med (Lausanne). 2021 Sep 3;8:720402. doi: 10.3389/fmed.2021.720402. eCollection 2021.
End-stage renal disease (ESRD) patients exhibit clinical features of premature ageing, including frailty, cardiovascular disease, and muscle wasting. Accelerated ageing also concerns the immune system. Patients with ESRD have both immune senescence and chronic inflammation that are resumed in the so-called inflammaging syndrome. Immune senescence is particularly characterised by premature loss of thymic function that is associated with hyporesponsiveness to vaccines, susceptibility to infections, and death. ESRD-related chronic inflammation has multiple causes and participates to accelerated cardiovascular disease. Although, both characterisation of immune senescence and its consequences are relatively well-known, mechanisms are more uncertain. However, prevention of immune senescence/inflammation or/and rejuvenation of the immune system are major goal to ameliorate clinical outcomes of ESRD patients.
终末期肾病（ESRD）患者表现出早衰的临床特征，包括身体虚弱、心血管疾病和肌肉萎缩。加速衰老也涉及免疫系统。ESRD患者存在免疫衰老和慢性炎症，这在所谓的炎症衰老综合征中表现出来。免疫衰老的特征尤其在于胸腺功能过早丧失，这与疫苗低反应性、易感染性和死亡相关。ESRD相关的慢性炎症有多种原因，并参与加速心血管疾病的发生。尽管免疫衰老的特征及其后果相对为人所知，但其机制仍较不确定。然而，预防免疫衰老/炎症和/或恢复免疫系统功能是改善ESRD患者临床结局的主要目标。
