Wijtenburg S Andrea, Yang Shaolin, Fischer Bernard A, Rowland Laura M
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA.
Department of Psychiatry, University of Illinois at Chicago, 1601 W. Taylor Street, Suite 512, Chicago, IL 60612, USA; Department of Radiology, University of Illinois at Chicago, 1601 W. Taylor Street, Suite 512, Chicago, IL 60612, USA; Department of Bioengineering, University of Illinois at Chicago, 1601 W. Taylor Street, Suite 512, Chicago, IL 60612, USA.
Neurosci Biobehav Rev. 2015 Apr;51:276-95. doi: 10.1016/j.neubiorev.2015.01.007. Epub 2015 Jan 19.
In vivo measurement of neurotransmitters and modulators is now feasible with advanced proton magnetic resonance spectroscopy ((1)H MRS) techniques. This review provides a basic tutorial of MRS, describes the methods available to measure brain glutamate, glutamine, γ-aminobutyric acid, glutathione, N-acetylaspartylglutamate, glycine, and serine at magnetic field strengths of 3T or higher, and summarizes the neurochemical findings in schizophrenia. Overall, (1)H MRS holds great promise for producing biomarkers that can serve as treatment targets, prediction of disease onset, or illness exacerbation in schizophrenia and other brain diseases.
利用先进的质子磁共振波谱（¹H MRS）技术，现在可以在体内测量神经递质和调质。本综述提供了MRS的基础教程，描述了在3T或更高磁场强度下测量脑内谷氨酸、谷氨酰胺、γ-氨基丁酸、谷胱甘肽、N-乙酰天冬氨酰谷氨酸、甘氨酸和丝氨酸的可用方法，并总结了精神分裂症的神经化学研究结果。总体而言，¹H MRS在生成生物标志物方面具有巨大潜力，这些生物标志物可作为精神分裂症和其他脑部疾病的治疗靶点、疾病发作预测或病情加重预测。
