Morgan Marsha K, Jones Paul A, Sobus Jon R, Chuang Jane C, Wilson Nancy K
a US EPA's National Exposure Research Laboratory , Research Triangle Park , NC , United States.
b Battelle , Columbus , OH , USA.
Int J Environ Health Res. 2015;25(6):628-39. doi: 10.1080/09603123.2014.1003039. Epub 2015 Jan 23.
Limited data exist on exposures of young children to polycyclic aromatic hydrocarbons (PAHs) in the United States (US). The urinary metabolite of pyrene, 1-hydroxypyrene (1-OHPyr), is widely used as a biomarker of total PAH exposure. Our objectives were to quantify urinary 1-OHPyr levels in 126 preschool children over a 48-h period and to examine associations between selected sociodemographic/lifestyle factors and urinary 1-OHPyr levels. Monitoring was performed at 126 homes and 16 daycares in Ohio in 2001, and questionnaires and urine samples were collected. The median urinary 1-OHPyr level was 0.33 ng/mL. In a multiple regression model, sampling season (p = 0.0001) and natural log (ln)-transformed creatinine concentration (p = 0.0006) were highly significant predictors of ln-transformed 1-OH-Pyr concentration; cooking appliance type (p = 0.096) was a marginally significant predictor of ln(1-OHPyr). These children had higher median urinary 1-OHPyr levels compared to other US children (≤ 0.15 ng/mL) in previously published studies, which suggests possible geographical differences in PAH exposure.
关于美国幼儿接触多环芳烃（PAHs）的数据有限。芘的尿代谢产物1-羟基芘（1-OHPyr）被广泛用作总PAH暴露的生物标志物。我们的目标是在48小时内对126名学龄前儿童的尿1-OHPyr水平进行量化，并研究选定的社会人口统计学/生活方式因素与尿1-OHPyr水平之间的关联。2001年在俄亥俄州的126个家庭和16个日托中心进行了监测，并收集了问卷和尿液样本。尿1-OHPyr水平的中位数为0.33 ng/mL。在多元回归模型中，采样季节（p = 0.0001）和自然对数（ln）转换后的肌酐浓度（p = 0.0006）是ln转换后的1-OH-Pyr浓度的高度显著预测因素；烹饪器具类型（p = 0.096）是ln（1-OHPyr）的边缘显著预测因素。与之前发表的研究中其他美国儿童（≤0.15 ng/mL）相比，这些儿童的尿1-OHPyr水平中位数更高，这表明PAH暴露可能存在地理差异。
