Farzan Shohreh F, Chen Yu, Trachtman Howard, Trasande Leonardo
Department of Epidemiology, Geisel School of Medicine at Dartmouth, One Medical Center Drive, Lebanon, NH 03756, USA; Department of Population Health, New York University School of Medicine, New York, NY, USA.
Department of Population Health, New York University School of Medicine, New York, NY, USA.
Environ Res. 2016 Jan;144(Pt A):149-157. doi: 10.1016/j.envres.2015.11.012. Epub 2015 Nov 21.
Recent evidence has suggested that polycyclic aromatic hydrocarbons (PAHs) may contribute to cardiometabolic and kidney dysfunction by increasing oxidative stress, but little is known about impacts in childhood.
We performed cross-sectional analyses of 660 adolescents aged 12-19 years in the 2003-2008 National Health and Nutrition Examination Survey (NHANES), using levels of 10 monohydroxylated urinary PAH metabolites as our exposure. Our primary outcomes of interest were biomarkers of oxidative stress and renal function, including estimated glomerular filtration rate (eGFR), urinary albumin to creatinine ratio (ACR), insulin resistance, and serum uric acid, gamma glutamyl transferase (GGT) and C-reactive protein (CRP).
We observed statistically significant associations between PAH metabolites and levels of serum GGT, CRP, uric acid and eGFR. Each 100% increase in 2-hydroxyphenanthrene was related to a 3.36% increase in uric acid (95% CI: 0.338-6.372; p=0.032), a 3.86% increase in GGT (95% CI: 1.361-6.362; p=0.005) and a 16.78% increase in CRP (95% CI: 1.848-31.689; p=0.029). Each 100% increase in 4-hydroxyphenanthrene was associated with a 6.18% increase in GGT (95% CI: 4.064-8.301; p<0.001) and a 13.66% increase in CRP (95% CI: 2.764-24.564; p=0.017). Each 100% increase in 9-hydroxyfluorene was associated with a 2.58% increase in GGT (95% CI: 0.389-4776; p=0.024). Each 100% increase in 3-hydroxyphenanthrene was associated with a 2.66% decrease in eGFR (95% CI: -4.979 to -0.331; p=0.028).
Urinary PAH metabolites were associated with serum uric acid, GGT and CRP, suggesting possible impacts on cardiometabolic and kidney function in adolescents. Prospective work is needed to investigate the potential long-term health consequences of these findings.
近期证据表明，多环芳烃（PAHs）可能通过增加氧化应激导致心脏代谢和肾脏功能障碍，但对儿童的影响知之甚少。
我们对2003 - 2008年国家健康与营养检查调查（NHANES）中660名12 - 19岁青少年进行了横断面分析，将10种单羟基化尿PAH代谢物水平作为暴露因素。我们感兴趣的主要结局是氧化应激和肾功能的生物标志物，包括估计肾小球滤过率（eGFR）、尿白蛋白与肌酐比值（ACR）、胰岛素抵抗、血清尿酸、γ-谷氨酰转移酶（GGT）和C反应蛋白（CRP）。
我们观察到PAH代谢物与血清GGT、CRP、尿酸和eGFR水平之间存在统计学显著关联。2-羟基菲每增加100%，与尿酸增加3.36%（95%CI：0.338 - 6.372；p = 0.032）、GGT增加3.86%（95%CI：1.361 - 6.362；p = 0.005）和CRP增加16.78%（95%CI：1.848 - 31.689；p = 0.029）相关。4-羟基菲每增加100%，与GGT增加6.18%（95%CI：4.064 - 8.301；p < 0.001）和CRP增加13.66%（95%CI：2.764 - 24.564；p = 0.017）相关。9-羟基芴每增加100%，与GGT增加2.58%（95%CI：0.389 - 4.
