茚达品增强豚鼠海马脑片苔藓纤维-CA3系统中的长时程增强效应。
Indeloxazine augments long-term potentiation in the mossy fiber-CA3 system of guinea pig hippocampal slices.
作者信息
Sugimura M, Ishihara K, Katsuki H, Satoh M
机构信息
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
出版信息
J Pharmacobiodyn. 1989 Dec;12(12):771-4. doi: 10.1248/bpb1978.12.771.
The effects of indeloxazine and piracetam, which reportedly prevent experimental impairments of memory and learning, on long-term potentiation (LTP) of the population spike in the mossy fiber-CA3 system were studied in vitro using the guinea pig hippocampal slices. Indeloxazine (10(-6) M) or piracetam (10(-4) M) significantly augmented the LTP and the effect of indeloxazine on the LTP was approximately 100 times as potent as that of piracetam.
据报道，茚达品和吡拉西坦可预防实验性记忆和学习障碍，本研究采用豚鼠海马脑片在体外研究了它们对苔藓纤维-CA3系统群体峰电位长时程增强（LTP）的影响。茚达品（10^(-6) M）或吡拉西坦（10^(-4) M）显著增强了LTP，且茚达品对LTP的作用约为吡拉西坦的100倍。
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