豚鼠海马脑片CA3区和CA1区长时程增强对益智药物的不同敏感性。

Different susceptibilities of long-term potentiations in CA3 and CA1 regions of guinea pig hippocampal slices to nootropic drugs.

作者信息

Satoh M, Ishihara K, Katsuki H

机构信息

Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University, Japan.

出版信息

Neurosci Lett. 1988 Nov 11;93(2-3):236-41. doi: 10.1016/0304-3940(88)90088-2.

DOI:10.1016/0304-3940(88)90088-2

PMID:2853846

Abstract

Effects of the nootropic drugs, piracetam and bifemelane, on long-term potentiation (LTP) of population spikes in the CA3 and CA1 regions of guinea pig hippocampal slices were investigated. Piracetam (10(-6) to 10(-4) M) and bifemelane (10(-8) to 10(-6) M) significantly augmented the LTP in the CA3 region. The effects of these drugs were inhibited by scopolamine (10(-6) M). However, the LTP in the CA1 region was not affected by piracetam and bifemelane even at highly effective concentrations (10(-5) and 10(-6) M, respectively). Thus, the LTP in the CA3 is more susceptible to nootropic drugs than in the CA1.

摘要

研究了促智药吡拉西坦和比呋内酰胺对豚鼠海马切片CA3和CA1区群体峰电位长时程增强（LTP）的影响。吡拉西坦（10⁻⁶至10⁻⁴ M）和比呋内酰胺（10⁻⁸至10⁻⁶ M）显著增强了CA3区的LTP。这些药物的作用被东莨菪碱（10⁻⁶ M）抑制。然而，即使在高效浓度（分别为10⁻⁵和10⁻⁶ M）下，CA1区的LTP也不受吡拉西坦和比呋内酰胺的影响。因此，CA3区的LTP比CA1区对促智药更敏感。