Sun Hanjun, Ji Haiwei, Ju Enguo, Guan Yijia, Ren Jinsong, Qu Xiaogang
Laboratory of Chemical Biology and Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 (P.R. China); University of the Chinese Academy of Science, Beijing, 100039 (P.R. China).
Chemistry. 2015 Feb 23;21(9):3791-7. doi: 10.1002/chem.201406345. Epub 2015 Jan 22.
Herein, a new strategy has been developed through combining a microwave-assisted technique with hydrothermal treatment to reduce graphene waste and improve production yield of graphene quantum dots (GQDs) prepared by top-down methods. By using fluorinated graphene oxide (FGO) as a raw material, fluorinated GQDs and nonfluorinated GQDs can be synthesized. Additionally, in the fluorinated GQDs, the protective shell supplied by fluorine improves the pH stability of photoluminescence and the strong electron-withdrawing group, -F, reduces the π-electron density of the aromatic structure; thus inhibiting reactivity toward singlet oxygen produced during irradiation and improving the photostability. Therefore, the as-prepared fluorinated GQDs with excellent photo- and pH stability are suitable for long-term cellular imaging.
在此，通过将微波辅助技术与水热处理相结合，开发了一种新策略，以减少石墨烯废料并提高通过自上而下方法制备的石墨烯量子点（GQD）的产率。以氟化氧化石墨烯（FGO）为原料，可以合成氟化GQD和非氟化GQD。此外，在氟化GQD中，氟提供的保护壳提高了光致发光的pH稳定性，并且强吸电子基团-F降低了芳族结构的π电子密度；因此抑制了对辐照过程中产生的单线态氧的反应性并提高了光稳定性。因此，所制备的具有优异光稳定性和pH稳定性的氟化GQD适用于长期细胞成像。
