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在致命病例中，CD206+细胞数量可区分甲型H1N1pdm09流感与季节性甲型流感病毒。

CD206+ cell number differentiates influenza A (H1N1)pdm09 from seasonal influenza A virus in fatal cases.

作者信息

Rodriguez-Ramirez Heidi G, Salinas-Carmona Mario C, Barboza-Quintana Oralia, Melo-de la Garza Americo, Ceceñas-Falcon Luis Angel, Rangel-Martinez Lilia M, Rosas-Taraco Adrian G

机构信息

Department of Immunology, School of Medicine and University Hospital, Universidad Autonoma de Nuevo Leon (UANL), Gonzalitos 235 Norte, Mitras Centro, 64460 Monterrey, NL, Mexico.

Servicio de Anatomia Patologica y Citopatologia, School of Medicine and University Hospital, Universidad Autonoma de Nuevo Leon (UANL), Monterrey, NL, Mexico.

出版信息

Mediators Inflamm. 2014;2014:921054. doi: 10.1155/2014/921054. Epub 2014 Nov 25.

DOI:10.1155/2014/921054
PMID:25614715
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4295401/
Abstract

In 2009, a new influenza A (H1N1) virus affected many persons around the world. There is an urgent need for finding biomarkers to distinguish between influenza A (H1N1)pdm09 and seasonal influenza virus. We investigated these possible biomarkers in the lung of fatal cases of confirmed influenza A (H1N1)pdm09. Cytokines (inflammatory and anti-inflammatory) and cellular markers (macrophages and lymphocytes subpopulation markers) were analyzed in lung tissue from both influenza A (H1N1)pdm09 and seasonal influenza virus. High levels of IL-17, IFN-γ, and TNF-α positive cells were identical in lung tissue from the influenza A (H1N1)pdm09 and seasonal cases when compared with healthy lung tissue (P < 0.05). Increased IL-4+ cells, and CD4+ and CD14+ cells were also found in high levels in both influenza A (H1N1)pdm09 and seasonal influenza virus (P < 0.05). Low levels of CD206+ cells (marker of alternatively activated macrophages marker in lung) were found in influenza A (H1N1)pdm09 when compared with seasonal influenza virus (P < 0.05), and the ratio of CD206/CD14+ cells was 2.5-fold higher in seasonal and noninfluenza group compared with influenza A (H1N1)pdm09 (P < 0.05). In conclusion, CD206+ cells differentiate between influenza A (H1N1)pdm09 and seasonal influenza virus in lung tissue of fatal cases.

摘要

2009年，一种新型甲型H1N1流感病毒感染了世界各地许多人。迫切需要找到生物标志物来区分甲型H1N1流感病毒（pdm09）和季节性流感病毒。我们在确诊的甲型H1N1流感病毒（pdm09）致死病例的肺部研究了这些可能的生物标志物。对甲型H1N1流感病毒（pdm09）和季节性流感病毒感染患者的肺组织中的细胞因子（炎性和抗炎性）及细胞标志物（巨噬细胞和淋巴细胞亚群标志物）进行了分析。与健康肺组织相比，甲型H1N1流感病毒（pdm09）和季节性流感病例的肺组织中IL-17、IFN-γ和TNF-α阳性细胞水平均较高（P<0.05）。甲型H1N1流感病毒（pdm09）和季节性流感病毒感染患者中还发现IL-4+细胞以及CD4+和CD14+细胞水平升高（P<0.05）。与季节性流感病毒相比，甲型H1N1流感病毒（pdm09）感染患者肺组织中CD206+细胞（肺组织中交替活化巨噬细胞标志物）水平较低（P<0.05），与甲型H1N1流感病毒（pdm09）感染组相比，季节性流感和非流感组中CD206/CD14+细胞比值高2.5倍（P<0.05）。总之，CD206+细胞可区分致死病例肺组织中的甲型H1N1流感病毒（pdm09）和季节性流感病毒。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8cb/4295401/06e8f8a25208/MI2014-921054.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8cb/4295401/65bbd8f3696e/MI2014-921054.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8cb/4295401/126708d08bcb/MI2014-921054.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8cb/4295401/c494212d0bd5/MI2014-921054.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8cb/4295401/06e8f8a25208/MI2014-921054.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8cb/4295401/65bbd8f3696e/MI2014-921054.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8cb/4295401/126708d08bcb/MI2014-921054.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8cb/4295401/c494212d0bd5/MI2014-921054.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8cb/4295401/06e8f8a25208/MI2014-921054.006.jpg

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