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鲁比前列酮通过胶囊内镜检查降低小肠转运时间：一项探索性、随机、双盲、安慰剂对照的三交叉研究。

Lubiprostone decreases the small bowel transit time by capsule endoscopy: an exploratory, randomised, double-blind, placebo-controlled 3-way crossover study.

作者信息

Matsuura Mizue, Inamori Masahiko, Endo Hiroki, Matsuura Tetsuya, Kanoshima Kenji, Inoh Yumi, Fujita Yuji, Umezawa Shotaro, Fuyuki Akiko, Uchiyama Shiori, Higurashi Takuma, Ohkubo Hidenori, Sakai Eiji, Iida Hiroshi, Nonaka Takashi, Futagami Seiji, Kusakabe Akihiko, Maeda Shin, Nakajima Atsushi

机构信息

Hepatology and Gastroenterology, Yokohama City University Hospital, Kanagawa, Yokohama 236-0004, Japan.

Office of Postgraduate Medical Education, Yokohama City University Hospital, 3-9 Fukuura, Kanazawa-ku, Kanagawa, Yokohama 236-0004, Japan.

出版信息

Gastroenterol Res Pract. 2014;2014:879595. doi: 10.1155/2014/879595. Epub 2014 Dec 29.

DOI:10.1155/2014/879595
PMID:25614738
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4295152/
Abstract

The aim of this study was to investigate the usefulness of lubiprostone for bowel preparation and as a propulsive agent in small bowel endoscopy. Six healthy male volunteers participated in this randomized, 3-way crossover study. The subjects received a 24 μg tablet of lubiprostone 60 minutes prior to the capsule ingestion for capsule endoscopy (CE) and a placebo tablet 30 minutes before the capsule ingestion (L-P regimen), a placebo tablet 60 minutes prior to CE and a 24 μg tablet of lubiprostone 30 minutes prior to CE (P-L regimen), or a placebo tablet 60 minutes prior to r CE and a placebo tablet again 30 minutes prior to CE (P-P regimen). The quality of the capsule endoscopic images and the amount of water in the small bowel were assessed on 5-point scale. The median SBTT was 178.5 (117-407) minutes in the P-P regimen, 122.5 (27-282) minutes in the L-P regimen, and 110.5 (11-331) minutes in the P-L regimen (P = 0.042). This study showed that the use of lubiprostone significantly decreased the SBTT. We also confirmed that lubiprostone was effective for inducing water secretion into the small bowel during CE.

摘要

本研究旨在探究鲁比前列酮在肠道准备及小肠内镜检查中作为推进剂的效用。六名健康男性志愿者参与了这项随机、三交叉研究。受试者在胶囊内镜检查（CE）吞服胶囊前60分钟服用24μg鲁比前列酮片，在吞服胶囊前30分钟服用安慰剂片（L-P方案）；或在CE前60分钟服用安慰剂片，在CE前30分钟服用24μg鲁比前列酮片（P-L方案）；或在CE前60分钟和CE前30分钟均服用安慰剂片（P-P方案）。胶囊内镜图像质量和小肠内水量采用5分制进行评估。P-P方案的小肠传输时间（SBTT）中位数为178.5（117 - 407）分钟，L-P方案为122.5（27 - 282）分钟，P-L方案为110.5（11 - 331）分钟（P = 0.042）。本研究表明，使用鲁比前列酮可显著缩短SBTT。我们还证实，鲁比前列酮在胶囊内镜检查期间可有效诱导小肠分泌液体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1050/4295152/b54662f0c704/GRP2014-879595.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1050/4295152/b54662f0c704/GRP2014-879595.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1050/4295152/b54662f0c704/GRP2014-879595.001.jpg

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Biomed Res Int. 2017;2017:3762179. doi: 10.1155/2017/3762179. Epub 2017 Dec 7.
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