Department of Emergency, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China.
Department of Integrated Traditional Chinese and Western Medicine, Shanghai Tong Ren Hospital, Shanghai 200050, China.
Evid Based Complement Alternat Med. 2014;2014:323870. doi: 10.1155/2014/323870. Epub 2014 Dec 28.
The study aimed at testing the hypothesis that tongxinluo capsule might exert its cardioprotective effect by preventing ventricular remodeling and improving coronary microvascular function in a rat model of doxorubicin-induced dilated cardiomyopathy (DCM). Rats that survived DCM induction were randomly divided into three groups to be given 1.5 g·kg(-1)·day(-1) (TXL-H, n = 9) or 0.15 g·kg(-1)·day(-1) (TXL-L, n = 10) of tongxinluo, or normal saline at the same volume (DCM-C, n = 10) intragastrically. Age matched normal rats treated with normal saline were used as normal controls (NOR-C, n = 9). After four weeks of treatment, the DCM-C, TXL-H, and TXL-L groups exhibited significant cardiac dysfunction, left ventricular remodeling, and coronary microvascular dysfunction, compared with the NOR-C rats. However, myocardial functional parameters were significantly improved and microvascular density (MVD) increased in the TXL-H group compared with the DCM-C group (all P < 0.01). Left ventricular remodeling was prevented. There were close linear relationships between CVF and LVEF (r = -0.683, P < 0.05), MVD and LVEF (r = 0.895, P < 0.05), and MVD and CVF (r = -0.798, P < 0.05). It was indicated that high-dose tongxinluo effectively improved cardiac function in rat model of DCM.
该研究旨在检验通心络胶囊通过预防心室重构和改善阿霉素诱导的扩张型心肌病（DCM）大鼠模型的冠状动脉微血管功能来发挥其心脏保护作用的假说。存活下来的 DCM 诱导大鼠被随机分为三组，分别给予 1.5 g·kg(-1)·天(-1)（TXL-H，n = 9）或 0.15 g·kg(-1)·天(-1)（TXL-L，n = 10）的通心络或相同体积的生理盐水（DCM-C，n = 10）灌胃。用生理盐水治疗的年龄匹配正常大鼠用作正常对照（NOR-C，n = 9）。经过四周的治疗，与 NOR-C 大鼠相比，DCM-C、TXL-H 和 TXL-L 组表现出明显的心功能障碍、左心室重构和冠状动脉微血管功能障碍。然而，与 DCM-C 组相比，TXL-H 组的心肌功能参数显著改善，微血管密度（MVD）增加（均 P < 0.01）。左心室重构得到预防。CVF 与 LVEF（r = -0.683，P < 0.05）、MVD 与 LVEF（r = 0.895，P < 0.05）和 MVD 与 CVF（r = -0.798，P < 0.05）之间存在密切的线性关系。这表明高剂量通心络可有效改善 DCM 大鼠模型的心脏功能。
