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用于硫酸软骨素控释的壳聚糖水凝胶：分析表征

Chitosan hydrogels for chondroitin sulphate controlled release: an analytical characterization.

作者信息

Bianchera Annalisa, Salomi Enrico, Pezzanera Matteo, Ruwet Elisabeth, Bettini Ruggero, Elviri Lisa

机构信息

Department of Pharmacy, University of Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy.

出版信息

J Anal Methods Chem. 2014;2014:808703. doi: 10.1155/2014/808703. Epub 2014 Dec 31.

DOI:10.1155/2014/808703
PMID:25614850
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4295592/
Abstract

This paper provides an analytical characterization of chitosan scaffolds obtained by freeze-gelation toward the uptake and the controlled release of chondroitin sulphate (CS), as cartilage repair agent, under different pH conditions. Scanning electron microscopy (SEM), attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), and liquid chromatography-UV spectrophotometry (LC-UV) techniques were exploited to obtain qualitative and quantitative descriptions of polymer and drug behaviour in the biomaterial. As for morphology, SEM analysis allowed the evaluation of scaffold porosity in terms of pore size and distribution both at the surface (Feret diameter 58 ± 19 μm) and on the cross section (Feret diameter 106 ± 51 μm). LC and ATR-FTIR evidenced a pH-dependent CS loading and release behaviour, strongly highlighting the role of electrostatic forces on chitosan/chondroitin sulphate interactions.

摘要

本文对通过冷冻凝胶法制备的壳聚糖支架进行了分析表征，该支架用于在不同pH条件下摄取和控制释放作为软骨修复剂的硫酸软骨素（CS）。利用扫描电子显微镜（SEM）、衰减全反射傅里叶变换红外光谱（ATR-FTIR）和液相色谱-紫外分光光度法（LC-UV）技术对生物材料中聚合物和药物的行为进行定性和定量描述。在形态方面，SEM分析能够评估支架在表面（费雷特直径58±19μm）和横截面上（费雷特直径106±51μm）的孔径和分布的孔隙率。LC和ATR-FTIR证明了CS的负载和释放行为依赖于pH值，突出了静电力在壳聚糖/硫酸软骨素相互作用中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8630/4295592/ecab67e16f95/JAMC2014-808703.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8630/4295592/d7f3b0458079/JAMC2014-808703.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8630/4295592/491e3749d4b1/JAMC2014-808703.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8630/4295592/ec8290336507/JAMC2014-808703.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8630/4295592/f3087ad9f1be/JAMC2014-808703.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8630/4295592/ecab67e16f95/JAMC2014-808703.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8630/4295592/d7f3b0458079/JAMC2014-808703.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8630/4295592/491e3749d4b1/JAMC2014-808703.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8630/4295592/ec8290336507/JAMC2014-808703.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8630/4295592/f3087ad9f1be/JAMC2014-808703.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8630/4295592/ecab67e16f95/JAMC2014-808703.005.jpg

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