Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, China.
Org Lett. 2015 Feb 6;17(3):644-7. doi: 10.1021/ol503666b. Epub 2015 Jan 23.
Armochaeglobines A (1) and B (2), two indole-based cytochalasan alkaloids with new carbon skeletons, were obtained from the fungus Chaetomium globosum TW1-1, which was first isolated from the arthropod Armadillidium vulgare. Their structures were elucidated by extensive spectroscopic analyses, ECD calculation, and single-crystal X-ray diffraction analysis. Interestingly, compound 1 featured a unique tetracyclic 5/6/7/5 fused ring system and 2 possessed a rare 12-membered carbon scaffold.
阿莫卡洛宾 A（1）和 B（2）是两种基于吲哚的细胞松弛素生物碱，具有全新的碳骨架，它们是从首次从节肢动物犰狳栉蚕中分离出来的真菌 Chaetomium globosum TW1-1 中获得的。通过广泛的光谱分析、ECD 计算和单晶 X 射线衍射分析阐明了它们的结构。有趣的是，化合物 1 具有独特的四环 5/6/7/5 稠合环系统，而 2 则具有罕见的 12 元碳支架。
