沙雷肽菌素 A 和 B，两种来自沙漠土壤来源真菌的新型细胞毒性细胞松弛素
Chaetomadrasins A and B, Two New Cytotoxic Cytochalasans from Desert Soil-Derived Fungus 375.
机构信息
Henan Joint International Research Laboratory of Drug Discovery of Small Molecules, Zhengzhou Key Laboratory of Synthetic Biology of Natural Products, Huanghe Science and Technology College, Zhengzhou, Henan 450063, China.
Institute of Microbiology, Chinese Academy of Science, Beijing 100101, China.
出版信息
Molecules. 2019 Sep 5;24(18):3240. doi: 10.3390/molecules24183240.
Two new cytochalasans, Chaetomadrasins A () and B (), along with six known analogues (-), were isolated from the solid-state fermented culture of desert soil-derived 375. Their structures were clarified by comprehensive spectroscopic analyses, and the absolute configurations of Compounds and were confirmed by electronic circular dichroism (ECD) and calculated ECD. For the first time, Chaetomadrasins A (1), which belongs to the chaetoglobosin family, is characterized by the presence of all oxygen atoms in the form of Carbonyl. Chaetomadrasin B () represents the first example of chaetoglobosin type cytochalasan characterized by a hydroxy unit and carbonyl group fused to the indole ring. Compounds and displayed moderate cytotoxicity against HepG2 human hepatocellular carcinoma cells.
从沙漠土壤来源的 375 的固态发酵培养物中分离得到两种新的细胞松弛素，即 Chaetomadrasin A () 和 B ()，以及六种已知类似物 (-)。通过全面的光谱分析阐明了它们的结构，并通过电子圆二色性 (ECD) 和计算 ECD 确定了化合物 和 的绝对构型。首次发现 Chaetomadrasin A (1) 属于 chaetoglobosin 家族，其特点是所有氧原子均以羰基的形式存在。Chaetomadrasin B () 代表了第一个以吲哚环上的羟基单元和羰基融合为特征的 chaetoglobosin 型细胞松弛素。化合物 和 对 HepG2 人肝癌细胞表现出中等的细胞毒性。
Zotero 插件