球毛壳菌素Y，一种来自球毛壳菌的新型细胞松弛素。

Chaetoglobosin Y, a new cytochalasan from Chaetomium globosum.

作者信息

Zheng Qi-Chang, Kong Ming-Zhu, Zhao Qin, Chen Guo-Dong, Tian Hai-Yan, Li Xiao-Xia, Guo Liang-Dong, Li Jia, Zheng Yi-Zhi, Gao Hao

机构信息

Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.

Shenzhen Key Laboratory of Microbial Genetic Engineering, College of Life Sciences, Shenzhen University, Shenzhen 518060, PR China.

出版信息

Fitoterapia. 2014 Mar;93:126-31. doi: 10.1016/j.fitote.2013.12.022. Epub 2014 Jan 11.

DOI:10.1016/j.fitote.2013.12.022

PMID:24418656

Abstract

Chaetoglobosin Y (1), was isolated from the endolichenic fungal strain Chaetomium globosum (No. 64-5-8-2), along with related six known cytochalasans, chaetoglobosin Fex (2), chaetoglobosin E (3), isochaetoglobosin D (4), chaetoglobosin G (5), cytoglobosin B (6), and cytoglobosin C (7). Their structures were determined by detailed spectroscopic analyses and comparison with those of the closely related compounds previously reported. The cytotoxicity to HCT-116 cell line of 2-7 was evaluated in vitro with doxorubicin as positive control.

摘要

从内生地衣真菌球毛壳菌（编号64 - 5 - 8 - 2）中分离得到了球毛壳菌素Y（1），同时还得到了六种相关的已知细胞松弛素，分别是球毛壳菌素Fex（2）、球毛壳菌素E（3）、异球毛壳菌素D（4）、球毛壳菌素G（5）、细胞球菌素B（6）和细胞球菌素C（7）。通过详细的光谱分析并与先前报道的密切相关化合物的结构进行比较，确定了它们的结构。以阿霉素作为阳性对照，在体外评估了化合物2 - 7对HCT - 116细胞系的细胞毒性。