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固有淋巴细胞:功能与发育的新见解

Innate lymphoid cells: new insights into function and development.

作者信息

Cortez Victor S, Robinette Michelle L, Colonna Marco

机构信息

Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63018, United States.

Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63018, United States.

出版信息

Curr Opin Immunol. 2015 Feb;32:71-7. doi: 10.1016/j.coi.2015.01.004. Epub 2015 Jan 20.

DOI:10.1016/j.coi.2015.01.004
PMID:25615701
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4648536/
Abstract

Here, we illustrate the complexity of ILC subsets and discuss novel functions, focusing on emerging mechanisms of crosstalk with other immune cells and the microbiota. Furthermore, we highlight recent insights into the development of ILCs, including the common pathways they share as well as points of divergence between ILC groups and subsets.

摘要

在此,我们阐述了ILC亚群的复杂性,并讨论了其新功能,重点关注与其他免疫细胞和微生物群相互作用的新兴机制。此外,我们强调了对ILC发育的最新见解,包括它们共有的常见途径以及ILC群体和亚群之间的差异点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae2b/4648536/69ff68d8d9c2/nihms-661765-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae2b/4648536/69ff68d8d9c2/nihms-661765-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae2b/4648536/69ff68d8d9c2/nihms-661765-f0001.jpg

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Viral infection. Prevention and cure of rotavirus infection via TLR5/NLRC4-mediated production of IL-22 and IL-18.病毒感染。通过TLR5/NLRC4介导产生IL-22和IL-18预防和治疗轮状病毒感染。
Science. 2014 Nov 14;346(6211):861-5. doi: 10.1126/science.1256999.
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Interleukin-22 regulates the complement system to promote resistance against pathobionts after pathogen-induced intestinal damage.
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Immunol Res. 2025 Apr 16;73(1):71. doi: 10.1007/s12026-025-09629-2.
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