Chan Lily, Mehrani Yeganeh, Minott Jessica A, Bridle Byram W, Karimi Khalil
Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada.
Department of Clinical Science, School of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad P.O. Box 91775-1111, Iran.
Vaccines (Basel). 2023 Oct 3;11(10):1559. doi: 10.3390/vaccines11101559.
Dendritic cell (DC) vaccines can stimulate the immune system to target cancer antigens, making them a promising therapy in immunotherapy. Clinical trials have shown limited effectiveness of DC vaccines, highlighting the need to enhance the immune responses they generate. Innate lymphoid cells (ILCs) are a diverse group of innate leukocytes that produce various cytokines and regulate the immune system. These cells have the potential to improve immunotherapies. There is not much research on how group 2 ILCs (ILC2s) communicate with DC vaccines. Therefore, examining the roles of DC vaccination in immune responses is crucial. Our research analyzed the effects of DC vaccination on the ILC2 populations and their cytokine production. By exploring the relationship between ILC2s and DCs, we aimed to understand how this could affect DC-based immunotherapies. The results showed an increase in the number of ILC2s in the local draining lymph node and spleen of tumor-free mice, as well as in the lungs of mice challenged with tumors in a pulmonary metastasis model. This suggests a complex interplay between DC-based vaccines and ILC2s, which is further influenced by the presence of tumors.
树突状细胞（DC）疫苗可以刺激免疫系统靶向癌症抗原，使其成为免疫治疗中一种有前景的疗法。临床试验表明DC疫苗的有效性有限，这凸显了增强其产生的免疫反应的必要性。固有淋巴细胞（ILC）是一类多样的固有白细胞，可产生多种细胞因子并调节免疫系统。这些细胞具有改善免疫治疗的潜力。关于2型固有淋巴细胞（ILC2）如何与DC疫苗相互作用的研究并不多。因此，研究DC疫苗接种在免疫反应中的作用至关重要。我们的研究分析了DC疫苗接种对ILC2群体及其细胞因子产生的影响。通过探索ILC2与DC之间的关系，我们旨在了解这如何影响基于DC的免疫治疗。结果显示，在无肿瘤小鼠的局部引流淋巴结和脾脏中，以及在肺转移模型中受肿瘤攻击的小鼠的肺中，ILC2的数量增加。这表明基于DC的疫苗与ILC2之间存在复杂的相互作用，而肿瘤的存在会进一步影响这种相互作用。
