Miyatake S, Hara Y, Maeda K, Akamine A, Eto M, Yamada K, Aono M
Nihon Shishubyo Gakkai Kaishi. 1989 Mar;31(1):318-26. doi: 10.2329/perio.31.318.
The purpose of this study was to evaluate the efficacy of porous hydroxyapatite (HAP) as an implant material into human periodontal defects. Thirty three patients affected by marginal periodontitis were studied. Following initial therapy, 44 periodontal osseous defects received grafts of HAP granules and blocks during flap surgery. Radiographic and various clinical examinations were performed before surgery and 1 and 2 weeks, and 1, 2, 3, 6 and more than 6 months after surgery. The results were as follows: 1. Postsurgical inflammation of the gingiva disappeared in a short time. Further more open wounds and discharges of HAP disappeared in the first month. There were no clinical problems in the sites receiving HAP implantation. 2. Radiographic demarcation lines between the implanted HAP and the surrounding alveolar bone became unclear at the beginning of bone repair. 3. At six months after surgery, the mean values of gingival recession, decrease in pocket depth and clinical attachment gain were respectively 0.9 mm, 2.7 mm, 1.9 mm. Additional observation beyond 6 months showed an attachment gain of 2.0 mm. 4. The attachment gain was less in the cases of one wall osseous defect and of furcation involvement in lower molars. These results suggest that HAP implantation is clinically effective, however, careful application is needed for the cases of one wall osseous defect or furcation involvement.
本研究的目的是评估多孔羟基磷灰石(HAP)作为植入材料用于人类牙周缺损的疗效。对33例患边缘性牙周炎的患者进行了研究。初始治疗后,44个牙周骨缺损在翻瓣手术期间接受了HAP颗粒和块状物移植。在手术前、术后1周和2周以及术后1、2、3、6个月和6个月以上进行了影像学和各种临床检查。结果如下:1.牙龈的术后炎症在短时间内消失。此外,HAP的开放性伤口和分泌物在第一个月消失。接受HAP植入的部位没有临床问题。2.在骨修复开始时,植入的HAP与周围牙槽骨之间的影像学分界线变得不清晰。3.术后6个月,牙龈退缩、牙周袋深度减少和临床附着增加的平均值分别为0.9毫米、2.7毫米、1.9毫米。6个月后的额外观察显示附着增加2.0毫米。4.单壁骨缺损和下颌磨牙根分叉病变病例的附着增加较少。这些结果表明,HAP植入在临床上是有效的,然而,对于单壁骨缺损或根分叉病变病例需要谨慎应用。