Raymon L P, Kimes A S, Tabakoff B, London E D
NIDA-Addiction Research Center, Baltimore, MD 21224.
C R Seances Soc Biol Fil. 1989;183(5):407-18.
The neurological complications associated with infection by the AIDS virus, HIV, occurs at an early stage of the disease and often indicate a poor prognosis. A dementia, known as AIDS Dementia Complex, is the most common feature observed, and is found in a majority of patients. The effects of gp120, the external protein envelope of HIV, on cerebral glucose utilization were studied in rats. Intracerebroventricular injection of gp120 significantly reduced glucose utilization in the lateral habenula and the suprachiasmatic nucleus, two regions rich in receptors for Vasoactive Intestinal Peptide (VIP) and the whole brain metabolism showed a significant decrease. The findings suggest that gp120 may alter neuronal function, thereby contributing to sequelae of HIV infection of the brain, and that attachment of HIV particles may involve, for a part, VIP receptors.
与艾滋病病毒（HIV）感染相关的神经并发症在疾病早期就会出现，且常常预示着预后不良。一种名为艾滋病痴呆综合征的痴呆症是最常见的症状，大多数患者都会出现。研究人员在大鼠身上研究了HIV外部蛋白包膜gp120对脑葡萄糖利用的影响。脑室内注射gp120可显著降低外侧缰核和视交叉上核（这两个区域富含血管活性肠肽（VIP）受体）的葡萄糖利用，且全脑代谢也显著下降。这些发现表明，gp120可能会改变神经元功能，从而导致HIV脑部感染的后遗症，并且HIV颗粒的附着可能部分涉及VIP受体。
