Kimes A S, London E D, Szabo G, Raymon L, Tabakoff B
Neuropharmacology Laboratory, National Institute on Drug Abuse, Baltimore, Maryland 21224.
Exp Neurol. 1991 May;112(2):224-8. doi: 10.1016/0014-4886(91)90073-l.
Gp-120 is a glycoprotein constituent of the human immunodeficiency virus (HIV) envelope. The effects of gp-120 on cerebral glucose utilization in rats were studied by the quantitative 2-deoxy-D-[1-14C] glucose method. Intracerebroventricular injection of gp-120 significantly reduced glucose utilization in the lateral habenula and the suprachiasmatic nucleus and decreased the global cerebral metabolic rate for glucose. The findings suggest that gp-120 and closely related peptides can alter neuronal function, thereby contributing to the sequelae of HIV infection.
Gp - 120是人类免疫缺陷病毒（HIV）包膜的一种糖蛋白成分。采用定量2 - 脱氧 - D - [1 - 14C]葡萄糖法研究了Gp - 120对大鼠脑葡萄糖利用的影响。脑室内注射Gp - 120可显著降低外侧缰核和视交叉上核的葡萄糖利用，并降低全脑葡萄糖代谢率。这些发现表明，Gp - 120及密切相关的肽可改变神经元功能，从而导致HIV感染的后遗症。
