Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/Nanomaterials and Technology, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, People's Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/Nanomaterials and Technology, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, People's Republic of China.
Biomaterials. 2015 Mar;44:91-102. doi: 10.1016/j.biomaterials.2014.12.035. Epub 2015 Jan 12.
This work develops a kind of sodium alginate (SA) microcapsules as microwave susceptible agents for in vivo tumor microwave thermal therapy for the first time. Due to the excellent microwave susceptible properties and low bio-toxicity, excellent therapy efficiency can be achieved with the tumor inhibiting ratio of 97.85% after one-time microwave thermal therapy with ultralow power (1.8 W, 450 MHz). Meanwhile, the mechanism of high microwave heating efficiency was confirmed via computer-simulated model in theory, demonstrating that the spatial confinement efficiency of microcapsule walls endows the inside ions with high microwave susceptible properties. This strategy offers tremendous potential applications in clinical tumor treatment with the benefits of safety, reliability, effectiveness and minimally invasiveness.
本工作首次开发了一种海藻酸钠（SA）微胶囊作为用于体内肿瘤微波热疗的微波敏化剂。由于具有优异的微波敏化性能和低生物毒性，仅进行一次微波热疗（1.8 W，450 MHz），即可达到 97.85%的肿瘤抑制率，实现优异的治疗效果。同时，通过理论计算机模拟模型确认了高微波加热效率的机制，表明微胶囊壁的空间限制效率赋予了内部离子高的微波敏化性能。该策略具有安全性、可靠性、有效性和微创性等优点，在临床肿瘤治疗方面具有巨大的应用潜力。
