急性髓系白血病中核型正常且无可检测突变的白血病原始细胞的红细胞吞噬现象。
Erythrophagocytosis by leukemic blasts in acute myeloid leukemia with a normal karyotype and no detectable mutations.
作者信息
Collins N Grant, O'Connor Heather M, Lindsey Kathryn G
机构信息
Department of Pathology and Laboratory Medicine, Medical University of South CarolinaCharlestonSouth Carolina.
出版信息
Proc (Bayl Univ Med Cent). 2019 Oct 25;33(1):65-66. doi: 10.1080/08998280.2019.1674051. eCollection 2020 Jan.
The phagocytosis of erythrocytes by leukemic blasts is a rare finding in acute myeloid leukemia and has been reported most commonly in monocytic and megakaryocytic morphologies. In the reported cases, erythrophagocytosis by leukemic blasts has been associated with t(8;16). This translocation is associated with a poor outcome independent of erythrophagocytosis. There has only been one reported case of erythrophagocytosis by leukemic blasts occurring in a patient with a normal karyotype. We report a 62-year-old woman with acute myeloid leukemia with monocytic features and a normal karyotype noted to have erythrophagocytosis by leukemic blasts.
白血病原始细胞吞噬红细胞在急性髓系白血病中是一种罕见现象，最常见于单核细胞和巨核细胞形态。在已报道的病例中，白血病原始细胞的红细胞吞噬现象与t(8;16)相关。这种易位与不良预后相关，与红细胞吞噬无关。仅有一例报道的白血病原始细胞红细胞吞噬现象发生在核型正常的患者中。我们报告了一名62岁具有单核细胞特征且核型正常的急性髓系白血病女性患者，其白血病原始细胞存在红细胞吞噬现象。
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