Department of Cell Biology, Erasmus Medical Center, Rotterdam, The Netherlands;
INSERM UMRS 1138, Team 17, Paris, France; and.
Blood. 2015 Mar 5;125(10):1521-5. doi: 10.1182/blood-2014-11-567925. Epub 2015 Jan 23.
An intimate relationship exists between nuclear architecture and gene activity. Unraveling the fine-scale three-dimensional structure of the genome and its impact on gene regulation is a major goal of current epigenetic research, one with direct implications for understanding the molecular mechanisms underlying human phenotypic variation and disease susceptibility. In this context, the novel revolutionary genome editing technologies and emerging new ways to manipulate genome folding offer new promises for the treatment of human disorders.
核架构与基因活性之间存在着密切的关系。解析基因组的精细三维结构及其对基因调控的影响是当前表观遗传学研究的主要目标之一，这对于理解人类表型变异和疾病易感性的分子机制具有直接意义。在这种情况下，新型革命性的基因组编辑技术和新兴的基因组折叠操作方法为人类疾病的治疗带来了新的希望。
