Center of Diabetes, Endocrinology and Metabolism, Toho University, Sakura Medical Center, 564-1, Shimoshizu, Sakura-City, Chiba 285-8741, Japan; Center of Endocrinology and Metabolism, Shin-Oyama City Hospital, 1-1-5, Wakagi-cho, Oyama-City, Tochigi 323-0028, Japan.
Center of Diabetes, Endocrinology and Metabolism, Toho University, Sakura Medical Center, 564-1, Shimoshizu, Sakura-City, Chiba 285-8741, Japan.
Atherosclerosis. 2015 Mar;239(1):163-8. doi: 10.1016/j.atherosclerosis.2015.01.011. Epub 2015 Jan 17.
To investigate the association of serum uric acid (SUA) with arterial stiffness assessed by cardio-ankle vascular index (CAVI).
We analyzed the cross-sectional data from 27,360 healthy Japanese subjects (12,910 males and 14,450 females) aged between 20 and 74 years without a past history of heart disease, stroke, hypertension, diabetes, nephritis or gout. We investigated whether SUA was independently associated with CAVI in a gender-specific manner.
BMI, CAVI, systolic/diastolic BP, GOT, GPT, γ-GTP, triglyceride (TG), creatinine and SUA were higher and HDL-C was lower in males than in females. Next, they were stratified by SUA into 3 groups: lower tertile (T1), middle tertile (T2) and upper tertile (T3) and by gender. CAVI increased progressive with increasing SUA tertile, after adjusting for age, BMI and systolic BP (sBP) identified in multiple regression analysis for CAVI. Multivariate analysis showed that the odds ratios (95% CI) relative to T1 for high CAVI (≥90(th) percentile) were 1.233 (0.928-1.638) in T2 and 1.352 (1.031-1.773) in T3 for males, and 1.133 (0.984-1.303) in T2 and 1.361 (1.098-1.687) in T3 for females, after adjusting for confounders. Furthermore, increase in adjusted CAVI was observed in a lower SUA range in females compared to that observed in males.
We demonstrated an independent correlation between SUA and CAVI, and observed gender difference in the SUA range for increase in CAVI. These results may suggest the need to set different target SUA levels for men and women in anti-hyperuricemic treatment for atherosclerosis prevention.
探讨血清尿酸（SUA）与心血管踝臂指数（CAVI）评估的动脉僵硬度的相关性。
我们分析了 27360 名年龄在 20 至 74 岁之间、无心脏病、中风、高血压、糖尿病、肾炎或痛风病史的日本健康受试者的横断面数据（男性 12910 名，女性 14450 名）。我们以性别特异性的方式研究了 SUA 是否与 CAVI 独立相关。
BMI、CAVI、收缩压/舒张压、GOT、GPT、γ-GTP、甘油三酯（TG）、肌酐和 SUA 在男性中高于女性，而高密度脂蛋白胆固醇（HDL-C）则低于女性。然后，根据 SUA 将他们分为 3 组：低三分位数（T1）、中三分位数（T2）和高三分位数（T3），并按性别分层。在多元回归分析中，CAVI 随着 SUA 三分位数的增加而逐渐升高，校正了年龄、BMI 和收缩压（SBP）。多元分析显示，男性 T2 时高 CAVI（≥90 百分位）的比值比（95%CI）相对于 T1 为 1.233（0.928-1.638），T3 时为 1.352（1.031-1.773），女性 T2 时为 1.133（0.984-1.303），T3 时为 1.361（1.098-1.687），校正混杂因素后。此外，与男性相比，女性在较低的 SUA 范围内观察到调整后的 CAVI 增加。
我们证明了 SUA 与 CAVI 之间存在独立的相关性，并观察到 SUA 增加与 CAVI 之间的性别差异。这些结果可能表明，在抗高尿酸血症治疗预防动脉粥样硬化时，需要为男性和女性设定不同的目标 SUA 水平。
