青霉素及其他细胞壁合成抑制剂处理期间，分泌至溶菌缺陷型肺炎链球菌生长培养基中的细胞壁聚合物的特性分析
Characterization of cell wall polymers secreted into the growth medium of lysis-defective pneumococci during treatment with penicillin and other inhibitors of cell wall synthesis.
作者信息
Hakenbeck R, Waks S, Tomasz A
出版信息
Antimicrob Agents Chemother. 1978 Feb;13(2):302-11. doi: 10.1128/AAC.13.2.302.
Abstract
Autolysin-defective pneumococci secrete large quantities of choline-containing cell wall polymers into the growth medium during treatment with inhibitors of peptidoglycan synthesis. The secreted polymers were separated into three fractions by a combination of gel filtration on agarose and sodium dodecyl sulfate-gel electrophoresis. Fraction I had a high apparent molecular size and contained the Forssman antigen in complex with material exhibiting properties of cell wall teichoic acid. Choline-containing polymers of as yet uncharacterized structure were present in both fractions IIA and IIB, and fraction IIA also contained peptidoglycan components.
摘要
在使用肽聚糖合成抑制剂处理期间，自溶素缺陷型肺炎球菌会向生长培养基中分泌大量含胆碱的细胞壁聚合物。通过琼脂糖凝胶过滤和十二烷基硫酸钠凝胶电泳相结合的方法，将分泌的聚合物分离成三个组分。组分I具有较高的表观分子大小，并且含有与表现出细胞壁磷壁酸特性的物质复合的福斯曼抗原。结构尚未明确的含胆碱聚合物存在于组分IIA和IIB中，并且组分IIA还含有肽聚糖成分。
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