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Cellular metabolism in genetic transformation of pneumococci: requirement for protein synthesis during induction of competence.肺炎链球菌遗传转化中的细胞代谢：感受态诱导过程中蛋白质合成的需求
J Bacteriol. 1970 Mar;101(3):860-71. doi: 10.1128/jb.101.3.860-871.1970.
2
Relation of macromolecular synthesis in streptococci to efficiency of transformation by markers of homospecific and heterospecific origin.链球菌中大分子合成与同种和异种来源标记物转化效率的关系。
J Bacteriol. 1974 Mar;117(3):1158-70. doi: 10.1128/jb.117.3.1158-1170.1974.
3
Effect of competence induction on macromolecular synthesis in a group H streptococcus.能力诱导对B群链球菌大分子合成的影响。 （注：原文中“group H streptococcus”表述有误，推测应该是“group B streptococcus”，按照正确内容翻译如上，若坚持按照原文错误内容翻译则是：能力诱导对H群链球菌大分子合成的影响。 ）
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[Correlation between radiosensitivity and unbalanced macromolecular synthesis in Escherichia coli cells].[大肠杆菌细胞中放射敏感性与不平衡大分子合成之间的相关性]
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Mode of action of berninamycin. An inhibitor of protein biosynthesis.伯宁霉素的作用模式。一种蛋白质生物合成抑制剂。
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J Bacteriol. 1972 Mar;109(3):1221-31. doi: 10.1128/jb.109.3.1221-1231.1972.

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Functional analysis of the two-gene lysis system of the pneumococcal phage Cp-1 in homologous and heterologous host cells.肺炎球菌噬菌体Cp-1双基因裂解系统在同源和异源宿主细胞中的功能分析。
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10
Analysis of the complete nucleotide sequence and functional organization of the genome of Streptococcus pneumoniae bacteriophage Cp-1.肺炎链球菌噬菌体Cp-1基因组的完整核苷酸序列及功能组织分析。
J Virol. 1996 Jun;70(6):3678-87. doi: 10.1128/JVI.70.6.3678-3687.1996.

本文引用的文献

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CYCLICAL BEHAVIOR IN PNEUMOCOCCAL GROWTH AND TRANSFORMABILITY OCCASIONED BY ENVIRONMENTAL CHANGES.环境变化引发的肺炎球菌生长及转化能力的周期性行为
Proc Natl Acad Sci U S A. 1954 Feb;40(2):49-55. doi: 10.1073/pnas.40.2.49.
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THE KINETICS OF DNA UPTAKE BY HAEMOPHILUS INFLUENZAE.流感嗜血杆菌摄取DNA的动力学
J Gen Microbiol. 1964 Jun;35:391-400. doi: 10.1099/00221287-35-3-391.
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REGULATION OF THE TRANSFORMABILITY OF PHEUMOCOCCAL CULTURES BY MACROMOLECULAR CELL PRODUCTS.大分子细胞产物对肺炎球菌培养物转化能力的调节
Proc Natl Acad Sci U S A. 1964 Mar;51(3):480-7. doi: 10.1073/pnas.51.3.480.
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PENETRATION OF DEOXYRIBONUCLEIC ACID INTO HEMOPHILUS INFLUENZAE.脱氧核糖核酸进入流感嗜血杆菌的情况
Biochim Biophys Acta. 1963 Sep 17;76:25-39.
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INCORPORATION OF DEOXYRIBONUCLEIC ACID IN THE BACILLUS SUBTILIS TRANSFORMATION SYSTEM.脱氧核糖核酸在枯草芽孢杆菌转化系统中的掺入
J Bacteriol. 1963 Sep;86(3):392-400. doi: 10.1128/jb.86.3.392-400.1963.
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THE EFFECT OF ENVIRONMENTAL FACTORS ON TRANSFORMABILITY OF A STREPTOCOCCUS.环境因素对链球菌可转化性的影响
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On the nature of competence of transformable streptococci.关于可转化链球菌的能力性质。
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8
Effects of azatryptophan on bacterial enzymes and bacteriophage.氮杂色氨酸对细菌酶和噬菌体的影响。
Biochim Biophys Acta. 1958 Feb;27(2):330-44. doi: 10.1016/0006-3002(58)90340-8.
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Initiation of bacterial transformation.细菌转化的起始
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10
Incorporation of the amino acid analog tryptazan into the protein of Escherichia coli.将氨基酸类似物色氨酸掺入大肠杆菌的蛋白质中。
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肺炎链球菌遗传转化中的细胞代谢：感受态诱导过程中蛋白质合成的需求

Cellular metabolism in genetic transformation of pneumococci: requirement for protein synthesis during induction of competence.

作者信息

Tomasz A

出版信息

J Bacteriol. 1970 Mar;101(3):860-71. doi: 10.1128/jb.101.3.860-871.1970.

DOI:10.1128/jb.101.3.860-871.1970
PMID:4392399
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC250403/
Abstract

Metabolic inhibitors have differential effects on various phases of genetic transformation in pneumococci. Evidence is presented suggesting that, in addition to the competence factor, another specific protein or class of proteins is essential for the development of cellular "competence." The precise role of this protein(s) in genetic transformation is not known, but it seems essential for some function subsequent to the interaction of competence factor and cells.

摘要

代谢抑制剂对肺炎球菌遗传转化的各个阶段有不同的影响。有证据表明，除感受态因子外，另一种特定的蛋白质或一类蛋白质对于细胞“感受态”的形成至关重要。这种蛋白质在遗传转化中的确切作用尚不清楚，但它似乎对于感受态因子与细胞相互作用后的某些功能至关重要。