中药天然产物的提取方法。

Extraction methods of natural products from Traditional Chinese medicines.

作者信息

Zhang Jingyu, Han Jianying, Oyeleye Ayokunmi, Liu Miaomiao, Liu Xueting, Zhang Lixin

机构信息

Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.

出版信息

Methods Mol Biol. 2015;1263:177-85. doi: 10.1007/978-1-4939-2269-7_14.

DOI:10.1007/978-1-4939-2269-7_14

PMID:25618345

Abstract

In recent years, many research activities have focused on Natural Products (NPs) derived from Traditional Chinese medicines (TCMs), thus making a renaissance in the drug discovery process of TCMs. Maximizing the diversity of extracts from those plants is the key for the chemical biology process. Methods for the preparation and pretreatment of plant extracts are very important for further purification and discovery of active compounds present in minor quantities. In this chapter, two methods of extraction, including one of the most broadly applicable method (solvent extraction) and one newly developed technique (supercritical fluid extraction), have been described in detail.

摘要

近年来，许多研究活动都聚焦于源自中药的天然产物，从而使中药的药物发现过程得以复兴。使这些植物提取物的多样性最大化是化学生物学过程的关键。植物提取物的制备和预处理方法对于进一步纯化和发现少量存在的活性化合物非常重要。在本章中，详细描述了两种提取方法，包括一种应用最广泛的方法（溶剂萃取）和一种新开发的技术（超临界流体萃取）。