Parafiniuk M, Czerwiński F, Parafiniuk W
Patol Pol. 1989;40(3):293-309.
Twenty one surgical specimens of lung cancer were studied. Microangiography showed that the vascularization of the tumours did not depend either on the size or histology of carcinoma. Abundant vascularity of tumours was associated with the degree development of connective tissue--vascular stroma. Poor vascularity was linked with neoplastic blockade of vessels and the presence of necrosis. Besides the cancer tumour the vascular changes existed in all parts of the lung, but they were expressed most profusely in the surroundings of neoplastic infiltrate. The range of histological vascular changes was as follows: elastosis, inflammation, lumen obliteration (proliferation of intima), wall thickening (arterialization of veins), oedema, hyalinization, plasmorrhagia, fibrosis (scarring), presence of acid GAG, thrombosis. The most striking vascular changes were connected with hilar and intralobar localization of the tumour, the mildest with subpleural position. The intensity of vascular changes depended on the size of tumour and existence of necrosis. The extent of necrosis and the histological type of neoplasm exerted no essential effects in this respect. Inflammatory cell infiltration appeared abundantly in the direct vicinity of the tumour in adenocarcinoma, with hilar localization and displayed proportional dependence on the size of tumour and the extent of necrosis, but the tumours, whose diameter exceeded 6 cm, failed to have any effect on the intensity of the inflammatory cell reactions.
对21例肺癌手术标本进行了研究。微血管造影显示，肿瘤的血管形成既不取决于癌的大小，也不取决于其组织学类型。肿瘤丰富的血管与结缔组织 - 血管基质的发育程度相关。血管稀少与血管的肿瘤性阻塞和坏死的存在有关。除癌瘤外，肺部各部位均存在血管变化，但在肿瘤浸润周围表现最为明显。组织学上血管变化的范围如下：弹性组织变性、炎症、管腔闭塞（内膜增生）、管壁增厚（静脉动脉化）、水肿、玻璃样变、血浆渗出、纤维化（瘢痕形成）、酸性糖胺聚糖的存在、血栓形成。最显著的血管变化与肿瘤的肺门和叶内定位有关，最轻微的与胸膜下位置有关。血管变化的强度取决于肿瘤的大小和坏死的存在。在这方面，坏死程度和肿瘤的组织学类型没有本质影响。在腺癌中，炎症细胞浸润大量出现在肿瘤的直接周边，位于肺门部位，并且与肿瘤大小和坏死程度呈比例相关，但直径超过6 cm的肿瘤对炎症细胞反应的强度没有影响。
