Zieliński K W, Kulig A, Zieliński J
Pathol Res Pract. 1984 Mar;178(4):369-77. doi: 10.1016/S0344-0338(84)80029-1.
A comparative investigations of peripheral microvascular bed in various histological types of human primary lung carcinomas (squamous cell carcinomas, oat-cell carcinomas, adenocarcinomas and large cell carcinomas) have been performed. The study was performed on 52 cases of lung carcinoma (there were 49 cases from autopsy and 3 cases from surgery) and on 8 normal comparative cases for evaluation of unchanged bronchial mucosa. Tissue blocks were obtained from standardized parts of bronchus and contained the intra- and extrabronchial parts of tumour as well as the bordering bronchial mucosa. The relative capacities of: 1. anaplastic cells, 2. connective tissue in stroma, 3. intraluminal space of blood vessels, 4. degenerative anaplastic cells, 5. necrotic detritus, and 6. haemorrhages and erytrorrhages were estimated in carcinomatous tissue by the hit points method. In bronchial mucosa the capacities of: 1. intraluminal space of blood vessels, and 2. haemorrhages and erythrorrhages were recorded. Furthermore, the structure of peripheral microvascular bed was evaluated by constructing the distributive series of diameters of blood vessels. These distributive series were approximated with the analitical function. It was found that the largest capacity of blood vessels (with an extremely developed capillary segment of vascular bed) is in the intrabronchial part of squamous cell carcinomas. In the extrabronchial part of this type of carcinoma, the capacity of blood vessel is about three-times smaller than in the intrabronchial part (3.36% and 9.26%, respectively). The finest blood vessels of extrabronchial part undergo the most considerable reduction, in comparison with the ones in the intrabronchial part of squamous cell carcinoma. Oat-cell carcinomas show the smallest difference in vascularization of intra- and extrabronchial parts of tumor (4.38% and 3.33%, respectively).(ABSTRACT TRUNCATED AT 250 WORDS)
已对人类原发性肺癌的各种组织学类型（鳞状细胞癌、燕麦细胞癌、腺癌和大细胞癌）的外周微血管床进行了比较研究。该研究对52例肺癌病例（49例来自尸检，3例来自手术）以及8例正常对照病例进行，以评估未受影响的支气管黏膜。组织块取自支气管的标准化部位，包含肿瘤的支气管内和支气管外部分以及相邻的支气管黏膜。通过打点法估计癌组织中以下各项的相对容量：1. 间变细胞；2. 基质中的结缔组织；3. 血管腔内空间；4. 退行性间变细胞；5. 坏死碎屑；6. 出血和红细胞外渗。在支气管黏膜中记录了以下各项的容量：1. 血管腔内空间；2. 出血和红细胞外渗。此外，通过构建血管直径分布序列来评估外周微血管床的结构。这些分布序列用解析函数进行近似。发现血管容量最大（血管床的毛细血管段极度发达）的是鳞状细胞癌的支气管内部分。在这种类型的癌的支气管外部分，血管容量比支气管内部分小约三倍（分别为3.36%和9.26%）。与鳞状细胞癌支气管内部分的血管相比，支气管外部分最细的血管减少最为显著。燕麦细胞癌肿瘤的支气管内和支气管外部分的血管化差异最小（分别为4.38%和3.33%）。（摘要截短至250字）
