Khater M M, Hassib H B, Issa Y M, Mohammed S H
Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt.
Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt.
Talanta. 2015 Mar;134:546-553. doi: 10.1016/j.talanta.2014.11.018. Epub 2014 Nov 27.
Polymer membrane and chemically modified carbon paste (CMCP) sensors for determination of sertraline HCl (Ser-Cl) incorporating sertraline tetraphenylborate (Ser-TPB) as an electro-active material were constructed. They showed a rapid and linear response for Ser-ion over the concentration range 0.01-10.00 mmol L(-1). The limits of detection were 2.80 and 9.55 μmol L(-1), and Nernastian slopes were 56.60, 59.60 mV decade(-1) for membrane and CMCP sensors for batch method. In flow injection analysis (FIA), the electrodes revealed comparatively good selectivity for Ser-ion with regard to a wide variety of different cations, sugars, and amino acids. The addition of different anionic additives, namely sodium tetraphenylborate (NaTPB), potassium tetraphenylborate (KTPB), potassium tetrakis[3,5-bis-(triflouromethyl)phenyl]borate (KTFMPB), and sodium tetrakis[3,5-bis(trifluoro-methyl)phenyl]borate (NaTFMPB), to the prepared mixture improved their response characteristics. The surface morphologies of membrane films containing PVC only (blank), plasticizer+PVC, Ser-TPB+plasticizer+PVC, and Ser-TPB +plasticizer+PVC+additive were studied using scanning and atomic force electron microscopes. These sensors had been used in the potentiometric titration of Ser-ion against NaTPB. Standard addition method for the pure raw material and some of its pharmaceutical tablets was used for Ser-Cl determination. The obtained results were tested for their repeatability and reproducibility and were statistically treated by F- and t- tests.
构建了用于测定盐酸舍曲林（Ser-Cl）的聚合物膜和化学修饰碳糊（CMCP）传感器，其中将舍曲林四苯基硼酸盐（Ser-TPB）用作电活性材料。它们在0.01 - 10.00 mmol L⁻¹的浓度范围内对Ser离子表现出快速且线性的响应。对于批量法的膜传感器和CMCP传感器，检测限分别为2.80和9.55 μmol L⁻¹，能斯特斜率分别为56.60、59.60 mV decade⁻¹。在流动注射分析（FIA）中，相对于多种不同的阳离子、糖类和氨基酸，这些电极对Ser离子显示出相对较好的选择性。向制备的混合物中添加不同的阴离子添加剂，即四苯基硼酸钠（NaTPB）、四苯基硼酸钾（KTPB）、四[3,5 - 双（三氟甲基）苯基]硼酸钾（KTFMPB）和四[3,5 - 双（三氟甲基）苯基]硼酸钠（NaTFMPB），改善了它们的响应特性。使用扫描电子显微镜和原子力显微镜研究了仅含PVC（空白）、增塑剂 + PVC、Ser-TPB + 增塑剂 + PVC以及Ser-TPB + 增塑剂 + PVC + 添加剂的膜的表面形态。这些传感器已用于Ser离子与NaTPB的电位滴定。采用标准加入法对纯原料及其一些药片中的Ser-Cl进行测定。对所得结果进行重复性和再现性测试，并通过F检验和t检验进行统计处理。
