Centre for Trophoblast Research, University of Cambridge and Department of Obstetrics and Gynaecology, University of Cambridge School of Clinical Medicine, National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre, The Rosie Hospital, Robinson Way, Cambridge CB2 0SW, UK.
Centre for Trophoblast Research, University of Cambridge and Department of Obstetrics and Gynaecology, University of Cambridge School of Clinical Medicine, National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre, The Rosie Hospital, Robinson Way, Cambridge CB2 0SW, UK.
Trends Mol Med. 2015 Feb;21(2):60-7. doi: 10.1016/j.molmed.2014.12.009. Epub 2015 Jan 22.
Much research in reproductive immunology is preoccupied with maternal tolerance of the semi-allogeneic fetus. This inevitably leads to the assumption that the maternal immune system should be suppressed, similarly to the immunosuppression needed to avoid rejection of an allograft. However, the parallels with transplantation immunology are misleading, and we discuss how interactions between variable immune system genes expressed on maternal natural killer (NK) cells and on the fetal trophoblast modulate fetal growth. Exaggerated suppression or activation of maternal NK cells associates with both extremes of birth weight.
生殖免疫学的许多研究都集中在母体对半同种异体胎儿的耐受性上。这不可避免地导致了这样一种假设，即母体的免疫系统应该被抑制，类似于为了避免同种异体移植物排斥而需要的免疫抑制。然而，与移植免疫学的相似之处具有误导性，我们讨论了表达在母体自然杀伤 (NK) 细胞和胎儿滋养层上的可变免疫系统基因之间的相互作用如何调节胎儿生长。母体 NK 细胞的过度抑制或激活与出生体重的两个极端都有关联。
