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Innate Lymphoid Cells: 10 Years On.先天淋巴细胞：十年进展。
Cell. 2018 Aug 23;174(5):1054-1066. doi: 10.1016/j.cell.2018.07.017.
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Natural Killer Cells Promote Fetal Development through the Secretion of Growth-Promoting Factors.自然杀伤细胞通过分泌促生长因子促进胎儿发育。
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The Transcription Factor NFIL3 Is Essential for Normal Placental and Embryonic Development but Not for Uterine Natural Killer (UNK) Cell Differentiation in Mice.转录因子NFIL3对小鼠正常胎盘和胚胎发育至关重要，但对子宫自然杀伤（UNK）细胞分化并非必需。
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The Residual Innate Lymphoid Cells in NFIL3-Deficient Mice Support Suboptimal Maternal Adaptations to Pregnancy.NFIL3基因缺陷小鼠中的残余先天性淋巴细胞支持母体对妊娠的次优适应性。
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Tissue-Resident NK Cells Mediate Ischemic Kidney Injury and Are Not Depleted by Anti-Asialo-GM1 Antibody.组织驻留自然杀伤细胞介导缺血性肾损伤且不被抗唾液酸GM1抗体耗尽。
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Composition, Development, and Function of Uterine Innate Lymphoid Cells.子宫固有淋巴细胞的组成、发育及功能
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Development, differentiation, and diversity of innate lymphoid cells.固有淋巴细胞的发育、分化及多样性
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HLA-G in human early pregnancy: control of uterine immune cell activation and likely vascular remodeling.人类早孕中的 HLA-G：对子宫免疫细胞激活和可能的血管重塑的控制。
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子宫自然杀伤细胞：保护与滋养。

Uterine natural killer cells: To protect and to nurture.

机构信息

Rheumatology Division, Washington University School of Medicine, St. Louis, Missouri.

出版信息

Birth Defects Res. 2018 Dec 1;110(20):1531-1538. doi: 10.1002/bdr2.1419. Epub 2018 Nov 22.

DOI:10.1002/bdr2.1419
PMID:30467993
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6309490/
Abstract

During the course of pregnancy, the maternal-fetal interface is tightly regulated and undergoes dynamic changes that promote the successful development of the semi-allogeneic fetus. In response to embryo implantation, the uterus remodels with maternal immune cells occupying the maternal-fetal interface and uterine natural killer (uNK) cells becoming the most prominent leukocyte. Recently, uNK cells have been discovered to be heterogeneous, including conventional NK and tissue-resident NK cells. Here, we will review the recent advances in uNK cell biology and discuss their functional mechanisms which protect and nurture the growing fetus.

摘要

在妊娠过程中，母胎界面受到严格调控，并发生动态变化，从而促进半同种异体胎儿的成功发育。为了应对胚胎着床，子宫进行重塑，母体免疫细胞占据母胎界面，而子宫自然杀伤(uNK)细胞成为最突出的白细胞。最近，人们发现 uNK 细胞具有异质性，包括常规 NK 细胞和组织驻留 NK 细胞。在这里，我们将回顾 uNK 细胞生物学的最新进展，并讨论它们保护和滋养不断成长的胎儿的功能机制。