Swain S M
Breast Evaluation Clinic, Vincent T. Lombardi Cancer Research Center, Georgetown University Medical Center.
Oncology (Williston Park). 1989 Mar;3(3):25-31; discussion 40, 42, 44 passim.
In situ breast cancer, both ductal and lobular, is being diagnosed more often today because of improved screening programs and more sensitive mammography. Unfortunately, treatment options in the disease are based on retrospective studies with the natural history obscured. While considered a noninvasive cancer, it has been theorized that ductal carcinoma in situ is a preinvasive stage that will eventually evolve into an invasive cancer. The author reviews results of studies comparing treatment methods, including wide local excision, mastectomy, and radiation, and concludes that prospective studies must be performed before optimal therapy can be determined.
由于筛查项目的改进和乳腺钼靶检查更加灵敏，如今原位乳腺癌（包括导管原位癌和小叶原位癌）的诊断更为常见。不幸的是，该疾病的治疗方案基于回顾性研究，其自然病史模糊不清。虽然导管原位癌被认为是非侵袭性癌症，但理论上它是一个侵袭前阶段，最终会演变成侵袭性癌症。作者回顾了比较治疗方法（包括广泛局部切除、乳房切除术和放疗）的研究结果，并得出结论，在确定最佳治疗方案之前必须进行前瞻性研究。
