Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Department of Endocrinology, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Clin Nutr. 2015 Dec;34(6):1101-8. doi: 10.1016/j.clnu.2014.12.019. Epub 2015 Jan 7.
Oxidative stress and inflammation have been proposed as emerging components of metabolic syndrome (MetS). Curcuminoids are natural polyphenols with strong antioxidant and anti-inflammatory properties.
To study the effectiveness of supplementation with a bioavailable curcuminoid preparation on measures of oxidative stress and inflammation in patients with MetS. Our secondary aim was to perform a meta-analysis of data from all randomized controlled trials in order to estimate the effect size of curcuminoids on plasma C-reactive protein (CRP) concentrations.
In this randomized double-blind placebo-controlled trial, 117 subjects with MetS (according to the NCEP-ATPIII diagnostic criteria) were randomly assigned to curcuminoids (n = 59; drop-outs = 9) or placebo (n = 58; drop-outs = 8) for eight weeks. Curcuminoids were administered at a daily dose of 1 g, and were co-supplemented with piperine (10 mg/day) in order to boost oral bioavailability. Serum activities of superoxide dismutase (SOD) and concentrations of malondialdehyde (MDA) and CRP were measured at baseline and at study end. Regarding the importance of CRP as a risk marker and risk factor of cardiovascular disease, a random-effects meta-analysis of clinical trials was performed to estimate the overall impact of curcuminoid therapy on circulating concentrations of CRP. The robustness of estimated effect size was evaluated using leave-one-out sensitivity analysis.
Supplementation with curcuminoid-piperine combination significantly improved serum SOD activities (p < 0.001) and reduced MDA (p < 0.001) and CRP (p < 0.001) concentrations compared with placebo. Quantitative data synthesis revealed a significant effect of curcuminoids vs. placebo in reducing circulating CRP concentrations (weighed mean difference: -2.20 mg/L; 95% confidence interval [CI]: -3.96, -0.44; p = 0.01). This effect was robust in sensitivity analysis.
Short-term supplementation with curcuminoid-piperine combination significantly improves oxidative and inflammatory status in patients with MetS. Curcuminoids could be regarded as natural, safe and effective CRP-lowering agents.
氧化应激和炎症被认为是代谢综合征（MetS）的新兴组成部分。姜黄素是具有强大抗氧化和抗炎特性的天然多酚。
研究补充生物可利用的姜黄素制剂对 MetS 患者氧化应激和炎症指标的影响。我们的次要目的是对所有随机对照试验的数据进行荟萃分析，以估计姜黄素对血浆 C 反应蛋白（CRP）浓度的影响大小。
在这项随机、双盲、安慰剂对照试验中，117 名符合 NCEP-ATPIII 诊断标准的 MetS 患者（根据 NCEP-ATPIII 诊断标准）被随机分配至姜黄素组（n = 59；脱落 9 人）或安慰剂组（n = 58；脱落 8 人），进行为期 8 周的治疗。姜黄素的日剂量为 1 g，并与胡椒碱（10 mg/天）联合补充，以提高口服生物利用度。在基线和研究结束时测量血清超氧化物歧化酶（SOD）活性以及丙二醛（MDA）和 CRP 浓度。鉴于 CRP 作为心血管疾病风险标志物和风险因素的重要性，对临床试验进行了随机效应荟萃分析，以估计姜黄素治疗对循环 CRP 浓度的总体影响。通过逐一剔除敏感性分析评估估计效应大小的稳健性。
与安慰剂组相比，姜黄素-胡椒碱联合补充显著提高了血清 SOD 活性（p < 0.001），降低了 MDA（p < 0.001）和 CRP（p < 0.001）浓度。定量数据分析显示，姜黄素与安慰剂相比，降低循环 CRP 浓度的效果具有统计学意义（加权均数差值：-2.20 mg/L；95%置信区间[CI]：-3.96，-0.44；p = 0.01）。该结果在敏感性分析中稳健。
短期补充姜黄素-胡椒碱联合制剂可显著改善 MetS 患者的氧化应激和炎症状态。姜黄素可被视为天然、安全、有效的 CRP 降低剂。
