School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore.
Centre for Biomimetic Sensor Science, Nanyang Technological University, 50 Nanyang Drive, 637553, Singapore.
Small. 2015 May;11(20):2372-9. doi: 10.1002/smll.201403638. Epub 2015 Jan 23.
The nanometer-scale discrimination of virus-rupturing peptides is tested using lipid membrane platforms. In combination with single-vesicle analysis of peptide-induced vesicle rupture, a correlation between membrane partitioning and biologically relevant activities is established. Taken together, the findings support that the degree of rupture activity should be balanced by membrane curvature-selectivity for optimal therapeutic properties of antiviral peptides.
病毒破裂肽的纳米级鉴别是使用脂质膜平台进行测试的。结合肽诱导的囊泡破裂的单囊泡分析，建立了膜分配与生物学相关活性之间的相关性。总的来说，这些发现支持了这样一种观点，即为了获得抗病毒肽的最佳治疗特性，破裂活性的程度应该通过膜曲率选择性来平衡。
