Berney Daniel M, Algaba Ferran, Amin Mahul, Delahunt Brett, Compérat Eva, Epstein Jonathan I, Humphrey Peter, Idrees Mohammed, Lopez-Beltran Antonio, Magi-Galluzzi Cristina, Mikuz Gregor, Montironi Rodolfo, Oliva Esther, Srigley John, Reuter Victor E, Trpkov Kiril, Ulbright Thomas M, Varma Murali, Verrill Clare, Young Robert H, Zhou Ming, Egevad Lars
Barts Cancer Institute, Queen Mary University of London, London, UK.
Fundacio Puigvert-University Autonomous, Barcelona, Spain.
Histopathology. 2015 Sep;67(3):313-24. doi: 10.1111/his.12657. Epub 2015 Mar 17.
The handling and reporting of testicular tumours is difficult due to their rarity.
A survey developed by the European Network of Uro-Pathology (ENUP) and sent to its members and experts to assess the evaluation of testicular germ cell tumours. Twenty-five experts and 225 ENUP members replied. Areas of disagreement included immaturity in teratomas, reported by 32% of experts but 68% of ENUP. Although the presence of rete testis invasion was reported widely, the distinction between pagetoid and stromal invasion was made by 96% of experts but only 63% of ENUP. Immunohistochemistry was used in more than 50% of cases by 68% of ENUP and 12% of experts. Staging revealed the greatest areas of disagreement. Invasion of the tunica vaginalis without vascular invasion was interpreted as T1 by 52% of experts and 67% of ENUP, but T2 by the remainder. Tumour invading the hilar adipose tissue adjacent to the epididymis without vascular invasion was interpreted as T1: 40% of experts, 43% of ENUP; T2: 36% of experts, 30% of ENUP; and T3: 24% of experts, 27% of ENUP.
There is remarkable consensus in many areas of testicular pathology. Significant areas of disagreement included staging and reporting of histological types, both of which have the potential to impact on therapy.
睾丸肿瘤因其罕见性，其处理和报告存在困难。
欧洲泌尿病理网络（ENUP）开展了一项调查，并将其发送给成员和专家，以评估睾丸生殖细胞肿瘤的评估情况。25名专家和225名ENUP成员进行了回复。存在分歧的领域包括畸胎瘤中的不成熟情况，32%的专家报告了这一情况，而ENUP成员中有68%报告了该情况。尽管睾丸网侵犯的情况被广泛报道，但96%的专家能区分派杰样浸润和间质浸润，而ENUP成员中只有63%能区分。68%的ENUP成员和12%的专家在超过50%的病例中使用了免疫组织化学。分期显示出最大的分歧领域。在无血管侵犯的情况下，鞘膜侵犯被52%的专家和67%的ENUP成员解释为T1，但其余人员解释为T2。肿瘤侵犯附睾旁的肾门脂肪组织且无血管侵犯时，40%的专家、43%的ENUP成员将其解释为T1；36%的专家、30%的ENUP成员解释为T2；24%的专家、27%的ENUP成员解释为T3。
在睾丸病理学的许多领域存在显著共识。存在重大分歧的领域包括分期和组织学类型的报告，这两者都有可能影响治疗。
