Lee A H, Theaker J M
Department of Histopathology, Southampton General Hospital, UK.
Histopathology. 1994 Apr;24(4):385-9. doi: 10.1111/j.1365-2559.1994.tb00542.x.
Germ cell neoplasia of the testis can spread into the rete testis in a pagetoid manner, but this is less often recognized than vascular invasion or direct spread into the tunica albuginea. The rete testis was studied in 71 orchidectomy specimens: 47 with an untreated germ cell tumour, 18 with germ cell neoplasia after treatment with chemotherapy, and six with other tumours. Pagetoid spread into the rete testis was seen in 14 of the 47 cases of germ cell tumour. The cytology of the infiltrating cells was that of intratubular germ cell neoplasia. Hyperplasia of the rete testis was seen in six cases. In three of the four testes with untreated germ cell neoplasia and hyperplasia of the rete, neoplastic cells were seen in the hyperplastic rete epithelium. The two testes with extensive pagetoid involvement of the rete testis by intratubular germ cell neoplasia both had associated hyperplasia of the rete testis. Two of the 18 testes with germ cell neoplasia after chemotherapy had focal hyperplasia. Pagetoid involvement of the rete testis by intratubular germ cell neoplasia is common and may be a cause of hyperplasia of the rete testis.
睾丸生殖细胞肿瘤可呈派杰样蔓延至睾丸网，但这种情况比血管侵犯或直接蔓延至白膜少见。对71例睾丸切除标本中的睾丸网进行了研究：47例为未经治疗的生殖细胞肿瘤，18例为化疗后出现生殖细胞肿瘤，6例为其他肿瘤。在47例生殖细胞肿瘤病例中，有14例可见派杰样蔓延至睾丸网。浸润细胞的细胞学表现为管内生殖细胞肿瘤。6例可见睾丸网增生。在4例未经治疗的生殖细胞肿瘤且睾丸网增生的睾丸中，有3例在增生的睾丸网上皮中可见肿瘤细胞。2例睾丸网广泛受管内生殖细胞肿瘤的派杰样累及的睾丸均伴有睾丸网增生。18例化疗后出现生殖细胞肿瘤的睾丸中有2例出现局灶性增生。管内生殖细胞肿瘤对睾丸网的派杰样累及很常见，可能是睾丸网增生的一个原因。
