对照受试者和原发性低丙种球蛋白血症患者B细胞克隆中淋巴细胞5'-核苷酸酶的动力学分析。
A kinetic analysis of lymphocyte 5'-nucleotidase in B-cell clones from control subjects and patients with primary hypogammaglobulinaemia.
作者信息
Barwick S E, Malkovsky M, Webster A D, Peters T J
机构信息
Division of Clinical Cell Biology, MRC Clinical Research Centre, Harrow, Middlesex, UK.
出版信息
J Clin Lab Immunol. 1989 Nov;30(3):117-20.
The affinity of lymphocyte 5'-nucleotidase (5NT) for its substrate adenosine monophosphate (AMP) was studied in Epstein-Barr virus immortalized B-lymphocyte clones from healthy controls and patients with primary hypogammaglobulinaemia. Km values for AMP for 5NT in most of the patient clones were found to be significantly increased compared to B-cell clones from normal subjects, whereas Vmax values were within the normal range.
在来自健康对照者和原发性低丙种球蛋白血症患者的爱泼斯坦 - 巴尔病毒永生化B淋巴细胞克隆中，研究了淋巴细胞5'-核苷酸酶（5NT）对其底物单磷酸腺苷（AMP）的亲和力。与正常受试者的B细胞克隆相比，发现大多数患者克隆中5NT对AMP的米氏常数（Km值）显著增加，而最大反应速度（Vmax值）在正常范围内。
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