De Berardis D, Conti C, Iasevoli F, Valchera A, Fornaro M, Cavuto M, Brucchi M, Perna G, Pompili M, Modabbernia A, Lucidi G, Mazza M, Martinotti G, Di Giannantonio M
Department of Mental Health, Psychiatric Service of Diagnosis and Treatment, Hospital G. Mazzini, ASL 4 Teramo, Italy.
Department of Neurosciences and Imaging, University G. DAnnunzio, Chieti, Italy.
J Biol Regul Homeost Agents. 2014 Oct-Dec;28(4):795-9.
The alexithymia construct is multidimensional and comprises several features: (a) difficulty in identifying and describing feelings, (b) difficulty in distinguishing feelings from the bodily sensations, (c) diminution of fantasy, and (d) concrete and poorly introspective thinking. Altered immune responses have been seen in some psychiatric disorders and several data suggest that analogous changes could also be observable in alexithymia. Hence, the aim of this review is to investigate the relationships between alexithymia and acute phase proteins and cytokines in psychiatric, psychosomatic and medical diseases. Several studies have reported an association between alexithymia and higher circulating levels of acute phase proteins, especially C-Reactive Protein. Moreover, in alexithymic subjects the pro-inflammatory and anti-inflammatory cytokine balance may be tuned toward a pro-inflammatory imbalance with a concomitant altered cell-mediated immunity. These findings may be consistent with the "stress-alexithymia hypothesis". Therefore, the screening of alexithymic traits and the administration of appropriate psychological and psychotherapeutical interventions should be integral parts of disease management programs. Supplying such interventions will probably help with prevention of the development of the disease and/or its exacerbation by improving the quality of life of alexithymic individuals.
述情障碍这一概念具有多维度性，包含几个特征：（a）难以识别和描述情感；（b）难以区分情感与身体感觉；（c）幻想减少；（d）思维具体且缺乏内省。在一些精神障碍中已观察到免疫反应改变，并且有多项数据表明在述情障碍中也可能观察到类似变化。因此，本综述的目的是研究述情障碍与精神疾病、身心疾病及医学疾病中急性期蛋白和细胞因子之间的关系。多项研究报告了述情障碍与急性期蛋白（尤其是C反应蛋白）循环水平升高之间的关联。此外，在述情障碍患者中，促炎和抗炎细胞因子平衡可能会朝着促炎失衡方向调整，同时细胞介导的免疫也会发生改变。这些发现可能与“应激 - 述情障碍假说”相符。因此，筛查述情障碍特征以及实施适当的心理和心理治疗干预应成为疾病管理计划的组成部分。提供此类干预可能有助于预防疾病的发展和/或通过改善述情障碍个体的生活质量来防止其病情加重。
