School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640 (P.R. China).
Angew Chem Int Ed Engl. 2015 Mar 2;54(10):3084-7. doi: 10.1002/anie.201410605. Epub 2015 Jan 23.
A base-promoted three-component coupling of carbon dioxide, amines, and N-tosylhydrazones has been developed. The reaction is suggested to proceed via a carbocation intermediate and constitutes an efficient and versatile approach for the synthesis of a wide range of organic carbamates. The advantages of this method include the use of readily available substrates, excellent functional group tolerance, wide substrate scope, and a facile work-up procedure.
已开发出一种基于碱的二氧化碳、胺和 N-对甲苯磺酰腙的三组分偶联反应。该反应被认为是通过碳正离子中间体进行的，为合成广泛的有机氨基甲酸酯提供了一种高效、通用的方法。该方法的优点包括使用易得的底物、对官能团具有优异的耐受性、广泛的底物范围以及简便的后处理步骤。
